Browse research papers in Toxicology - Pharmacology, Toxicology and Pharmaceutics Discover 7 academic papers with AI-powered analysis - Paperzilla

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Pharmacology, Toxicology and Pharmaceutics

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Toxicology

Toxicology

The study of adverse effects of chemicals, including mechanisms of toxicity, risk assessment, environmental toxicology, forensic toxicology, and regulatory toxicology

7 papers in this specialization

Papers

Human gut bacteria bioaccumulate per- and polyfluoroalkyl substances

This study found that human gut bacteria can accumulate high levels of PFAS, even at environmentally relevant concentrations, and this accumulation is increased in the absence of efflux pumps in *E. coli*. Experiments in mice colonized with human gut bacteria showed they excrete more PFAS in their feces than germ-free mice, suggesting that gut bacteria can influence PFAS levels in the host. Further research is needed to determine the long-term consequences of PFAS bioaccumulation on the gut microbiome and its impact on human health, especially under chronic low-dose exposure conditions.

s41564-025-02032-5.pdf

Jul 19, 05:03 PM

Teratogenic Effects of Serotonin Receptor 2B Disruption on the Migration and Cardiac Derivatives of the Cardiac Neural Crest

Disrupting serotonin signaling, specifically via 5-HT2B receptors, impairs the migration of cardiac neural crest cells in chick embryos. This leads to structural defects in the heart, including gaps in the aorticopulmonary septum and interventricular septal defects, potentially due to decreased cNCC proliferation.

Birth Defects Research - 2025 - Wells - Teratogenic Effects of Serotonin Receptor 2B Disruption on the Migration and.pdf

Jul 18, 01:50 PM

Pharmaceutical pollution of the world's rivers

Pharmaceutical contamination is widespread in the world's rivers, with the highest cumulative concentrations found in low-to-middle-income countries. This pollution poses a threat to both environmental and human health, potentially exceeding safe levels for aquatic organisms and contributing to antimicrobial resistance.

Jul 14, 05:11 PM

Injection fears and COVID-19 vaccine hesitancy

This UK study found that about a quarter of adults screen positive for a blood-injection-injury phobia, and these folks are twice as likely to report COVID-19 vaccine hesitancy. If this fear was poof, gone, about 1 in 10 cases of reported vaccine hesitancy might vanish too.

Jul 14, 11:27 AM

Redox-controlled chalcogen-bonding at tellurium: impact on Lewis acidity and chloride anion transport properties

Oxidative methylation of diaryltellurides enhances their Lewis acidity and chalcogen-bonding properties, resulting in improved chloride anion transport across lipid bilayers. This effect is attributed to the lowering of tellurium-centered σ* orbitals and deepening of associated σ-holes upon oxidation, making telluronium cations more effective anion transporters than their neutral precursors.

Jul 14, 11:27 AM

Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription

This study found that emodin, a natural compound from Chinese herbs, inhibits tumor angiogenesis and growth in triple-negative breast cancer (TNBC) models by increasing the expression of SerRS, a transcriptional repressor of VEGFA. Emodin directly interacts with NCOR2, leading to its dissociation from the SerRS promoter and subsequent SerRS activation.

Jul 14, 11:27 AM

Adverse events associated with JAK inhibitors in 126,815 reports from the WHO pharmacovigilance database

This study found JAK inhibitors were associated with increased reporting of infections, embolism/thrombosis, neoplasms, and gastrointestinal perforations. While some of these were already known, it raises further concerns about malignancies and gastrointestinal issues, though major cardiovascular events were not significantly associated.

s41598-022-10777-w.pdf

Jul 14, 11:27 AM

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