Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide

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Conflicts of Interest

Identified Weaknesses

Rating Explanation

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Paper Summary

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Rats on Trace Amounts of Roundup Show Hints of Liver Disease: A Multiomics Study

This rat study found changes in liver proteins and metabolites after two years of exposure to very low doses of Roundup, resembling those seen in human non-alcoholic fatty liver disease (NAFLD). However, the changes were small, and other factors could be involved. More research is needed to establish a causal link.

Possible Conflicts of Interest

None identified, although study funded by Sustainable Food Alliance (USA), which advocates for sustainable agriculture which could influence interpretation or presentation of the findings.

Identified Weaknesses

Small effect sizes and limited statistical power

While some changes were statistically significant, many were not due to high variability between individual rats. A larger study is needed to confirm these findings.

Correlation does not equal causation

The observed liver changes could be due to other factors. More research is needed to establish a direct causal link between Roundup and NAFLD.

Roundup is a mixture, not just glyphosate

Roundup contains other ingredients besides glyphosate, so we cannot rule out other chemicals may be involved. More studies with glyphosate only may determine other chemicals are to blame.

Rating Explanation

This study raises concerns about low-dose Roundup exposure and liver health. While suggestive, the small effect sizes, inherent limitations of animal studies, and inability to determine causality limit the strength of the conclusions. The funding source presents a potential conflict that cannot be ignored.

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