Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide
Overview
Paper Summary
This rat study found changes in liver proteins and metabolites after two years of exposure to very low doses of Roundup, resembling those seen in human non-alcoholic fatty liver disease (NAFLD). However, the changes were small, and other factors could be involved. More research is needed to establish a causal link.
Explain Like I'm Five
Rats given tiny amounts of Roundup in their drinking water for two years developed signs of liver disease similar to human NAFLD. This suggests even very low levels of Roundup might be harmful over time.
Possible Conflicts of Interest
None identified, although study funded by Sustainable Food Alliance (USA), which advocates for sustainable agriculture which could influence interpretation or presentation of the findings.
Identified Limitations
Rating Explanation
This study raises concerns about low-dose Roundup exposure and liver health. While suggestive, the small effect sizes, inherent limitations of animal studies, and inability to determine causality limit the strength of the conclusions. The funding source presents a potential conflict that cannot be ignored.
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