PAPERZILLA
Crunching Academic Papers into Bite-sized Insights.
About
Sign Out
← Back to papers
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology
Teratogenic Effects of Serotonin Receptor 2B Disruption on the Migration and Cardiac Derivatives of the Cardiac Neural Crest
★
★
★
★
☆
SHARE
Overview
Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
Good to know
Topic Hierarchy
File Information
Paper Summary
Paperzilla title
Bad Trip for Chick Embryos: Messing with Serotonin Makes Their Hearts Wonky
Disrupting serotonin signaling, specifically via 5-HT2B receptors, impairs the migration of cardiac neural crest cells in chick embryos. This leads to structural defects in the heart, including gaps in the aorticopulmonary septum and interventricular septal defects, potentially due to decreased cNCC proliferation.
Possible Conflicts of Interest
This work was supported by Loyola Marymount University. There was no mention of other possible conflicts of interest in the article.
Identified Weaknesses
Pharmacological approach limits receptor-specific conclusions
The study relies on pharmacological interventions that target both 5-HT2B and 5-HT2C receptors simultaneously, making it challenging to isolate the specific effects of each receptor on CNCC development. Genetic studies, such as receptor-specific knockouts, are necessary to confirm the individual roles of these receptors.
Lack of mechanistic insights
The study did not investigate the downstream molecular pathways involved in the observed phenotypes. Further research is needed to understand the mechanisms by which 5-HT2B and 5-HT2C receptor signaling affect CNCC migration, differentiation, and cardiac morphogenesis.
Relevance of IVS defect to avian model
The observed absence of a membranous interventricular septum is not a typical feature of avian heart development. This raises questions about the relevance of this specific phenotype to normal avian cardiogenesis.
Limited assessment of factors influencing observed phenotypes
While proliferation of cNCCs was reduced by 1-MP treatment, other potential causes of the cardiac defects, such as changes in cell death, and differentiation, were not directly assessed.
Rating Explanation
This study provides valuable insights into the role of serotonin receptors in cardiac neural crest cell development. The experimental design is generally well-executed, employing pharmacological interventions, whole-mount immunohistochemistry, and histological analysis. The findings are clearly presented and supported by statistical analysis. Despite some limitations, the study significantly advances our understanding of the complex interplay of factors regulating heart development.
Good to know
This is our free standard analysis. Paperzilla Pro fact-checks every citation, researches author backgrounds and funding sources, and uses advanced AI reasoning for more thorough insights.
Explore Pro →
Topic Hierarchy
File Information
Original Title:
Teratogenic Effects of Serotonin Receptor 2B Disruption on the Migration and Cardiac Derivatives of the Cardiac Neural Crest
File Name:
Birth Defects Research - 2025 - Wells - Teratogenic Effects of Serotonin Receptor 2B Disruption on the Migration and.pdf
[download]
File Size:
1.48 MB
Uploaded:
July 18, 2025 at 01:50 PM
Privacy:
🌐 Public
© 2025 Paperzilla. All rights reserved.