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Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology
Redox-controlled chalcogen-bonding at tellurium: impact on Lewis acidity and chloride anion transport properties
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Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
Supercharged Tellurium: Now It's a Chloride Transporter!
Oxidative methylation of diaryltellurides enhances their Lewis acidity and chalcogen-bonding properties, resulting in improved chloride anion transport across lipid bilayers. This effect is attributed to the lowering of tellurium-centered σ* orbitals and deepening of associated σ-holes upon oxidation, making telluronium cations more effective anion transporters than their neutral precursors.
Possible Conflicts of Interest
None identified
Identified Weaknesses
Lack of In Vivo Validation
The study primarily focuses on in vitro experiments, lacking in vivo validation to confirm the real-world applicability of the findings. Anion transport in living organisms involves complex biological environments and interactions that are not fully replicated in vitro.
Limited Scope of Anion Transport
The research investigates chloride transport, but its relevance to other anions and broader biological transport processes is unclear. Exploring the transport capabilities for other biologically relevant anions would strengthen the findings.
Reliance on Computational Models
While computational studies support the experimental observations, they rely on specific models and assumptions. The validity and generalizability of these computational findings need further investigation using different models and experimental validation.
Rating Explanation
This study presents a novel approach to enhancing chalcogen-bond donor properties and demonstrates its practical application in anion transport. The methodology is sound, and the findings are well-supported by experimental and computational data. While the study has some limitations regarding in vivo validation and scope, its innovative approach and robust methodology justify a strong rating.
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Topic Hierarchy
File Information
Original Title:
Redox-controlled chalcogen-bonding at tellurium: impact on Lewis acidity and chloride anion transport properties
File Name:
d0sc02872j.pdf
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File Size:
0.70 MB
Uploaded:
July 14, 2025 at 11:27 AM
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