Adverse drug reactions following SARS-CoV-2 vaccination of 3805 healthcare workers cause substantial sick-leave and are correlated to vaccine regimen, age, sex and serological response
Overview
Paper Summary
In a study of Swedish healthcare workers, different COVID-19 vaccine regimens were associated with varying rates of adverse drug reactions (ADRs), leading to significant sick leave in 12-48% of participants depending on the vaccine. The heterologous regimens and Spikevax were associated with the highest rates of side effects. Younger age and female sex correlated with increased risk of ADRs.
Explain Like I'm Five
Different COVID-19 vaccines caused different levels of side effects in healthcare workers, sometimes so bad they couldn't work. mRNA vaccines seemed to cause the fewest problems.
Possible Conflicts of Interest
One author (Anna-Karin Lidstrom) reported funding from the Olinder-Nielsen Family Foundation. The nature and extent of this funding's influence on the research is unclear.
Identified Limitations
Rating Explanation
This is a reasonably well-conducted observational study with a large sample size. However, its observational nature limits causal inferences, and the sample demographics may not be fully representative of all healthcare workers. The disclosed funding from a family foundation represents a potential, though not necessarily critical, conflict of interest.
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