Browse research papers in Cardiology and Cardiovascular Medicine - Medicine Discover 28 academic papers with AI-powered analysis

Influence of geomagnetic disturbances on myocardial infarctions in women and men from Brazil

This observational study found a correlation between geomagnetic disturbances and an increased incidence of myocardial infarctions, especially in women, in a single Brazilian city. The authors acknowledge that these findings are not conclusive and emphasize that the study highlights a hypothetical significance rather than a definitive cause-effect relationship.

★

☆

paper_2017.pdf

Sep 28, 02:05 PM

Initiation of Pregabalin vs Gabapentin and Development of Heart Failure

This retrospective cohort study of Medicare beneficiaries found that new users of pregabalin had an increased risk of heart failure compared to new users of gabapentin. The risk was particularly elevated in those with a history of cardiovascular disease. The study used a large dataset and controlled for over 200 potential confounding factors.

A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction

This single-center retrospective study developed and validated the H2FPEF score, a tool using clinical and echocardiographic data to estimate the probability of heart failure with preserved ejection fraction (HFpEF) in patients with unexplained dyspnea. The H2FPEF score showed good discrimination of HFpEF from other causes of dyspnea in both the derivation and validation cohorts.

Intensity or volume: the role of physical activity in longevity

This observational study of US adults suggests that higher intensity physical activity is more strongly linked to lower mortality risk than simply increasing the amount of activity, especially for cardiovascular disease. Accumulating intense activity in short bursts rather than spreading it out sporadically may also be beneficial.

Artificial intelligence automation of echocardiographic measurements

This study developed EchoNet-Measurements, a deep learning model, to automate 18 echocardiographic measurements. The model showed strong agreement with expert sonographers' measurements in multiple datasets from different healthcare systems, demonstrating its potential for reducing workload and improving measurement consistency.

Hyperkalemia in Heart Failure with Reduced Ejection Fraction: Implications and Management

This review explores the challenge of hyperkalemia (high potassium) in heart failure patients, especially those taking renin-angiotensin-aldosterone system inhibitors (RAASi) and mineralocorticoid receptor antagonists (MRAs). It discusses the importance of potassium monitoring, combining therapies like SGLT2 inhibitors with RAASi, and using newer non-steroidal MRAs and potassium binders to mitigate this risk.

Estimating cardiovascular effects of influenza vaccination in older adults: a target trial emulation using proximal causal inference

This large study from China found that people 65 and older who got flu shots had slightly fewer heart attacks and major adverse cardiovascular events. While they used fancy statistical methods to account for some biases, it's still not a perfect randomized trial, so we can't be 100% sure it's the flu shot itself causing the benefit.

Estimating cardiovascular effects of influenza vaccination in older adults: a target trial emulation using proximal causal inference

This large study of over 8 million older adults in China suggests that getting a flu shot might reduce the risk of major heart problems and acute coronary syndromes. The researchers used fancy statistical methods to minimize biases that are common in studies like this, making their findings a little more trustworthy.

Two-year outcomes of left bundle branch area pacing versus traditional right ventricular pacing in middle-aged adults: a registry-based trial

In this Italian registry-based trial of adults under 65, pacing the left bundle branch area was better than traditional right ventricular pacing at reducing the combined risk of cardiovascular death and heart failure hospitalization over two years. However, no significant differences were seen in cardiovascular or all-cause mortality alone. Several authors disclosed financial ties to device manufacturers.

Association of Coronary Plaque With Low-Density Lipoprotein Cholesterol Levels and Rates of Cardiovascular Disease Events Among Symptomatic Adults

In a large cohort of symptomatic patients undergoing coronary CT angiography, those with high LDL-cholesterol (≥190 mg/dL) and no coronary plaque or calcium buildup had a low risk of cardiovascular events. This suggests that the presence of plaque, especially calcified plaque, is a better indicator of risk than high LDL-C alone in this population, and could be used to better target intensive treatment.

Sex-specific body fat distribution predicts cardiovascular ageing

This study found that higher amounts of visceral fat (belly fat) are associated with an older "cardiovascular age" than expected for one's actual age, particularly in men. Gynoid fat (fat in the hips and thighs) showed a protective link to cardiovascular age in women. The study was limited by its predominantly white, UK Biobank population and cross-sectional design.

Risk reduction of ASCVD attributed to lowering of remnant cholesterol from statins, fibrates, APOC3 inhibitors, and ANGPTL3 inhibitors: a cohort study

This observational study suggests that lowering remnant cholesterol, as seen with new APOC3 and ANGPTL3 inhibitors, could reduce 10-year ASCVD risk by 2.7-4.1% in statin users and 1.4-2.1% in statin non-users with high remnant cholesterol. However, randomized controlled trials are needed to confirm these findings and establish causality.

Risk reduction of ASCVD attributed to lowering of remnant cholesterol from statins, fibrates, APOC3 inhibitors, and ANGPTL3 inhibitors: a cohort study

This observational cohort study suggests that lowering remnant cholesterol, as seen with new APOC3 and ANGPTL3 inhibitors, could reduce 10-year ASCVD risk by 1.4%-4.1%, with greater reductions seen in statin users. However, these are predictions based on observational data and previous genetic studies, assuming a causal link between remnant cholesterol and ASCVD; large randomized controlled trials are needed to confirm these findings.

Effect of intermittent fasting after ST-elevation myocardial infarction on left ventricular function: study protocol of a pilot randomised controlled trial (INTERFAST-MI)

This pilot study will examine the effect of an intermittent fasting regime (8/16 hour fast/feed cycle) on left ventricular ejection fraction in patients who recently had a heart attack. The small sample size (n=48) limits the study's power to detect a statistically significant benefit. The lack of blinding and single center design also weaken the study.

Left Bundle Branch Pacing in Patients with Structural Heart Disease: Personalizing Cardiac Resynchronization Therapy

Left bundle branch pacing (LBBP) can effectively resynchronize cardiac contraction in some heart failure patients, offering a more physiological approach compared to traditional biventricular pacing. However, individual patient characteristics, such as the presence of intraventricular conduction delay and myocardial scar, can influence the success of LBBP, requiring careful evaluation and potentially the addition of a coronary sinus lead. Careful patient selection, procedural considerations and long-term effects require further study.

LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature

This review argues that high LDL cholesterol does not cause cardiovascular disease, citing studies that found no association or an inverse association between LDL-C and mortality. However, the review suffers from cherry-picked data, misrepresentation of studies, and conflicts of interest, making its conclusions unreliable. It also downplays the established benefits of statin therapy.

Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation

This study, primarily conducted on mice, suggests that aspartame consumption may exacerbate atherosclerosis through an insulin-dependent mechanism involving the CX3CL1-CX3CR1 signaling pathway. The results were partially validated in monkeys, but with inconsistencies in blood glucose responses. Further research is needed to confirm these findings in humans and explore the effects of other artificial sweeteners.

★

☆

PIIS1550413125000063.pdf

Jul 21, 06:46 AM

2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)

These guidelines address cardiovascular care for cancer patients before, during, and after treatment, focusing on prevention, surveillance, and management of cancer therapy-related cardiovascular toxicity. They recommend baseline risk assessment, personalized surveillance protocols, and management strategies for various cancer therapies and cardiovascular conditions, emphasizing a multidisciplinary approach and patient involvement in care.

★

☆

Lyon-2022--esc-guidelines-on-cardio-oncology-.pdf

Jul 14, 05:17 PM

Valve Academic Research Consortium 3: updated endpoint definitions for aortic valve clinical research

This paper updates endpoint definitions for aortic valve clinical research, providing detailed criteria for evaluating mortality, neurologic events, hospitalization, bleeding, and valve dysfunction. The goal is to improve the homogeneity of data reporting and analysis in future clinical trials involving transcatheter and surgical aortic valve interventions.

2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)

These guidelines provide recommendations for cardiovascular risk assessment, prevention, and management in cancer patients and survivors. They emphasize a personalized approach to care based on individual risk factors, cancer type, and cancer therapies.

★

☆

Lyon-2022--esc-guidelines-on-cardio-oncology-.pdf

Jul 14, 05:12 PM

Efficient Prediction of Cardiovascular Disease Using Machine Learning Algorithms With Relief and LASSO Feature Selection Techniques

This study developed a hybrid Random Forest Bagging Method (RFBM) model combined with Relief feature selection for predicting heart disease. Using a combined dataset and 10 key features, the model achieved 99.05% accuracy, significantly outperforming existing models. This suggests RFBM with Relief is a promising approach for improving early diagnosis and mitigating cardiovascular disease mortality.

2022 ESC Guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery

The guidelines recommend a stepwise evaluation of the patient that integrates clinical risk factors and test results with the estimated stress of the planned surgical procedure and the risks involved with the discontinuation of drugs. This allows for individualized risk assessment and treatment strategies.

DIETARY FATS, CARBOHYDRATES AND ATHEROSCLEROTIC VASCULAR DISEASE (Concluded)

The review suggests that dietary carbohydrates play a minor role in serum lipid regulation compared to dietary fat and cholesterol. While some animal studies suggest a link between specific carbohydrates and lipid levels, these findings are limited by methodological issues and may not accurately reflect human metabolism. Longitudinal human trials are needed to definitively establish the role of carbohydrates in atherosclerosis.

★

☆

Mcgandy-1967-part-1-1.pdf

Jul 08, 12:12 PM

DIETARY FATS, CARBOHYDRATES AND ATHEROSCLEROTIC VASCULAR DISEASE

This 1967 review examines the relationship between dietary fats, carbohydrates, and atherosclerotic vascular disease. It summarizes epidemiological and controlled dietary studies, finding a complex interplay between diet and blood lipid levels, with dietary fat playing a more significant role than carbohydrates in influencing serum cholesterol. However, the review highlights the difficulty in isolating the specific contribution of diet due to the multitude of confounding factors.

★

☆

Mcgandy-1967-part-2-1.pdf

Jul 08, 11:51 AM

Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial

This case-cohort study found that light-to-moderate wine consumption, as measured by urinary tartaric acid levels, was associated with a lower risk of cardiovascular disease events in older Mediterranean adults at high risk. The strongest association was found for moderate wine consumption (estimated as up to 1 drink/day), specifically with a lower risk of myocardial infarction.

Cardiology and Cardiovascular Medicine

Paperzilla Papers in Cardiology and Cardiovascular Medicine

Influence of geomagnetic disturbances on myocardial infarctions in women and men from Brazil

Initiation of Pregabalin vs Gabapentin and Development of Heart Failure

A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction

Intensity or volume: the role of physical activity in longevity

Artificial intelligence automation of echocardiographic measurements

Hyperkalemia in Heart Failure with Reduced Ejection Fraction: Implications and Management

Estimating cardiovascular effects of influenza vaccination in older adults: a target trial emulation using proximal causal inference

Estimating cardiovascular effects of influenza vaccination in older adults: a target trial emulation using proximal causal inference

Two-year outcomes of left bundle branch area pacing versus traditional right ventricular pacing in middle-aged adults: a registry-based trial

Association of Coronary Plaque With Low-Density Lipoprotein Cholesterol Levels and Rates of Cardiovascular Disease Events Among Symptomatic Adults

Sex-specific body fat distribution predicts cardiovascular ageing

Risk reduction of ASCVD attributed to lowering of remnant cholesterol from statins, fibrates, APOC3 inhibitors, and ANGPTL3 inhibitors: a cohort study

Risk reduction of ASCVD attributed to lowering of remnant cholesterol from statins, fibrates, APOC3 inhibitors, and ANGPTL3 inhibitors: a cohort study

Accelerated vascular ageing after COVID-19 infection: the CARTESIAN study

Cardiovascular Damage Resulting from Chronic Excessive Endurance Exercise

Physiological pacing: mechanisms, clinical indications, and perspectives

Effect of intermittent fasting after ST-elevation myocardial infarction on left ventricular function: study protocol of a pilot randomised controlled trial (INTERFAST-MI)

Left Bundle Branch Pacing in Patients with Structural Heart Disease: Personalizing Cardiac Resynchronization Therapy

LDL-C does not cause cardiovascular disease: a comprehensive review of the current literature

Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation

2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)

Valve Academic Research Consortium 3: updated endpoint definitions for aortic valve clinical research

2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)

Efficient Prediction of Cardiovascular Disease Using Machine Learning Algorithms With Relief and LASSO Feature Selection Techniques

2022 ESC Guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery

DIETARY FATS, CARBOHYDRATES AND ATHEROSCLEROTIC VASCULAR DISEASE (Concluded)

DIETARY FATS, CARBOHYDRATES AND ATHEROSCLEROTIC VASCULAR DISEASE

Urinary tartaric acid as a biomarker of wine consumption and cardiovascular risk: the PREDIMED trial