A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction

★

☆

SHARE

Overview

Paper Summary

Conflicts of Interest

Identified Weaknesses

Rating Explanation

Good to know

Topic Hierarchy

File Information

Paper Summary

Paperzilla title

New H2FPEF Score Helps Diagnose Heart Failure With Preserved Ejection Fraction

This single-center retrospective study developed and validated the H2FPEF score, a tool using clinical and echocardiographic data to estimate the probability of heart failure with preserved ejection fraction (HFpEF) in patients with unexplained dyspnea. The H2FPEF score showed good discrimination of HFpEF from other causes of dyspnea in both the derivation and validation cohorts.

Possible Conflicts of Interest

None identified

Identified Weaknesses

Single-center study

The study was conducted at a single tertiary referral center, which may limit the generalizability of the findings to other populations and healthcare settings.

Retrospective design

Retrospective studies are inherently susceptible to biases related to data collection and interpretation.

Lack of external validation

The H2FPEF score was validated on a separate cohort from the same center, but external validation in diverse populations and settings is crucial to confirm its generalizability and performance.

Rating Explanation

This study presents a well-designed and executed approach to address the challenging diagnosis of HFpEF in patients with unexplained dyspnea. The development and validation of the H2FPEF score provide a practical tool with good discriminatory ability. However, the single-center, retrospective design, and lack of external validation warrant a slightly lower rating until further validation is performed.

Good to know

This is our free standard analysis. Paperzilla Pro fact-checks every citation, researches author backgrounds and funding sources, and uses advanced AI reasoning for more thorough insights.

Explore Pro →