Hyperkalemia in Heart Failure with Reduced Ejection Fraction: Implications and Management
Overview
Paper Summary
This review explores the challenge of hyperkalemia (high potassium) in heart failure patients, especially those taking renin-angiotensin-aldosterone system inhibitors (RAASi) and mineralocorticoid receptor antagonists (MRAs). It discusses the importance of potassium monitoring, combining therapies like SGLT2 inhibitors with RAASi, and using newer non-steroidal MRAs and potassium binders to mitigate this risk.
Explain Like I'm Five
Some heart failure medications can raise potassium levels, which is dangerous. Doctors need to carefully balance these medications with other treatments and close monitoring to keep potassium in a safe range.
Possible Conflicts of Interest
Funding and medical writing support were provided by Bayer US, LLC, which manufactures finerenone, a drug discussed in the article.
Identified Limitations
Rating Explanation
This is a well-written and comprehensive review of an important clinical issue in heart failure management. While it lacks primary data and specific subgroup recommendations, it effectively synthesizes current evidence and provides a practical guide for clinicians. The disclosed industry funding raises a potential conflict of interest, but the overall scientific rigor and balanced presentation maintain the rating of 4.
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