Browse research papers in Microbiology - Medicine Discover 5 academic papers with AI-powered analysis

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Microbiology

Medical microbiology and infectious agents, including bacterial, viral, fungal, and parasitic pathogens, antimicrobial resistance, diagnostic microbiology, and infection control

5 papers in this specialization

Papers

Antimicrobial activities evaluation and phytochemical screening of some selected medicinal plants: A possible alternative in the treatment of multidrug-resistant microbes

Methanolic extracts of several medicinal plants from Bale Zone, Ethiopia, showed promising in vitro antimicrobial activity against multidrug-resistant bacteria, particularly S. pyogenes. Rumex abyssinicus exhibited the strongest antifungal effect against C. albicans and T. mentagrophytes. Further studies are needed to validate these findings in vivo and assess their clinical efficacy, toxicity, and affordability.

Identification and antimicrobial susceptibility profiles of Nocardia species clinically isolated in Japan

Nocardia farcinica complex was the most prevalent species among clinical isolates in Japan, followed by N. cyriacigeorgica and N. brasiliensis. MALDI-TOF MS, using a supplemental Nocardia library, demonstrated high accuracy in species/complex identification. Linezolid exhibited 100% in vitro activity, while TMP-SMX retained good activity, although resistance varied among species.

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s41598-021-95870-2.pdf

Jul 14, 11:27 AM

Clinical characteristics and treatment of actinomycetoma in northeast Mexico: A case series

This case series analyzed 31 patients with actinomycetoma in northeast Mexico, finding Nocardia brasiliensis to be the most common cause. Most patients achieved a cure with combination antibiotic treatments including TMP/SMX plus amikacin or amoxicillin/clavulanic acid, showcasing successful management strategies for this neglected tropical disease.

Rapid Detection of Nocardia by Next-Generation Sequencing

This study found that next-generation sequencing (NGS) can detect Nocardia species in clinical samples faster than traditional culture methods, with a turnaround time of 48 hours compared to an average of 7.5 days. They also suggest a potential diagnostic cutoff based on Nocardia-specific reads ranking among the top two identified microbes, but this needs further validation.

Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of eumycetoma

This research screened a library of drug-like molecules for activity against five causative agents of eumycetoma, a neglected fungal disease. Four compounds (fenbendazole, carbendazim, tafenoquine, and MMV1578570) inhibited all five species in vitro, and four (fenbendazole, MMV1782387, ravuconazole, and olorofim) prolonged survival in an infected insect model. Benzimidazole carbamates, a class including fenbendazole and carbendazim, emerged as particularly promising candidates.