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Health Sciences › Medicine › Microbiology
Identification and antimicrobial susceptibility profiles of Nocardia species clinically isolated in Japan
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Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
MALDI-TOF MS: A Rapid and Reliable Tool for Identifying Nocardia Species in Japan
Nocardia farcinica complex was the most prevalent species among clinical isolates in Japan, followed by N. cyriacigeorgica and N. brasiliensis. MALDI-TOF MS, using a supplemental Nocardia library, demonstrated high accuracy in species/complex identification. Linezolid exhibited 100% in vitro activity, while TMP-SMX retained good activity, although resistance varied among species.
Possible Conflicts of Interest
The study received funding from the Kurozumi Medical Foundation and Charitable Trust Laboratory Medicine Research Foundation of Japan. No other conflicts were disclosed.
Identified Weaknesses
Small Sample Size for Uncommon Species
The study relies on a small sample size, particularly for uncommon Nocardia species, limiting the generalizability of the findings regarding species distribution and antimicrobial susceptibility profiles.
Limited Investigation of TMP-SMX Resistance Mechanisms
The lack of investigation into the mechanisms of TMP-SMX resistance in Nocardia, beyond screening for known plasmid-mediated genes, leaves a significant gap in understanding resistance development.
Lack of Clinical Outcome Data
The study doesn't include clinical outcome data, so the impact of MALDI-TOF MS-guided identification and susceptibility testing on patient management and treatment success remains unknown.
Rating Explanation
This study provides valuable insights into the distribution and antimicrobial susceptibility profiles of Nocardia species in Japan, contributing to improved diagnostic and treatment strategies. The use of MALDI-TOF MS for rapid and reliable species identification is a significant strength. However, limitations such as the small sample size for uncommon species, limited mechanistic exploration of TMP-SMX resistance, and the lack of clinical outcome data prevent a top rating.
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File Information
Original Title:
Identification and antimicrobial susceptibility profiles of Nocardia species clinically isolated in Japan
File Name:
s41598-021-95870-2.pdf
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File Size:
1.18 MB
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July 14, 2025 at 11:27 AM
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