Methanolic extracts of several medicinal plants from Bale Zone, Ethiopia, showed promising in vitro antimicrobial activity against multidrug-resistant bacteria, particularly S. pyogenes. Rumex abyssinicus exhibited the strongest antifungal effect against C. albicans and T. mentagrophytes. Further studies are needed to validate these findings in vivo and assess their clinical efficacy, toxicity, and affordability.

The research was collaboratively funded by Madda Walabu University and Kotebe Metropolitan University, which might introduce a potential bias. However, the paper states that the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

The study demonstrates promising in vitro antimicrobial activity of several plant extracts against MDR bacteria, especially S. pyogenes. However, the lack of in vivo validation, toxicity testing, mechanistic insights, and clinical efficacy data limits the impact of the findings. The potential conflict of interest due to funding sources is acknowledged, but their influence is stated to be minimal. Overall, the study provides preliminary findings that warrant further investigation, but it is not groundbreaking due to several methodological limitations.