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Pharmacology, Toxicology and Pharmaceutics
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Pharmacology
Pharmacology
Drug action and effects on biological systems, including molecular pharmacology, neuropharmacology, cardiovascular pharmacology, drug-receptor interactions, and adverse drug reactions
3 papers in this specialization
Papers
Imidazole propionate is a driver and therapeutic target in atherosclerosis
This study found that imidazole propionate (ImP), a metabolite produced by gut microorganisms, is associated with atherosclerosis in mice and humans. While the human data is correlational and derived from cohorts of limited diversity (Spanish and Swedish populations), experiments in mouse models suggest a causal role for ImP in driving atherosclerosis, particularly through activation of the immune response and the mTOR pathway in myeloid cells. Blocking ImP's interaction with the I1R receptor in mice prevented atherosclerosis development.
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s41586-025-09263-w.pdf
Jul 20, 06:38 AM
In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus
This study used computational methods to screen Chinese herbal medicines for potential activity against COVID-19. They identified 26 herbs traditionally used for respiratory infections that contain compounds predicted to inhibit viral proteins. However, these predictions require experimental confirmation.
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pmc7102521.pdf
Jul 14, 11:16 AM
Recent List of Cyclodextrin-Containing Drug Products
The paper presents a list of over 120 marketed pharmaceutical ingredients formulated with cyclodextrins or their derivatives, categorized by cyclodextrin cavity size, administration route, and dosage forms. The most commonly used are beta-cyclodextrin and its hydroxypropylated and sulfobutylated derivatives.
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9649.pdf
Jul 14, 11:16 AM
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