The effect of commonly used non-antibiotic medications on antimicrobial resistance development in Escherichia coli
Overview
Paper Summary
This in vitro study found that common non-antibiotic medications (NAMs) like ibuprofen and acetaminophen can increase ciprofloxacin resistance in E. coli, possibly by boosting mutations and overexpressing efflux pumps. Combinations of two NAMs further increased resistance. While done in bacterial cultures, this raises concerns about polypharmacy and warrants further research in more complex models.
Explain Like I'm Five
Some common non-antibiotic drugs, like ibuprofen and acetaminophen, can make E. coli more resistant to antibiotics, especially when taken with ciprofloxacin.
Possible Conflicts of Interest
None identified
Identified Limitations
Rating Explanation
This study provides compelling in vitro evidence for the effect of NAMs on antibiotic resistance development. The methodology is sound and provides valuable mechanistic insights via genomic analysis and efflux pump assessments. While the in vitro model has limitations in its applicability to humans, the findings are important and merit further investigation.
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