Bidirectional Effect of Long-Term Δ9-Tetrahydrocannabinol Treatment on mTOR Activity and Metabolome
Overview
Paper Summary
This study in mice found that long-term, low-dose THC treatment had distinct effects on brain and body metabolisms. In the brain, it initially increased mTOR activity and energy production, seemingly promoting synapse formation. Subsequently, it reduced mTOR activity and metabolic processes in adipose tissue, similar to the effects seen in calorie restriction. These findings suggest potential cognitive and anti-aging benefits of THC, but more research is needed to confirm these effects in humans.
Explain Like I'm Five
In old mice, long-term, low-dose THC temporarily boosted brain activity and synapse formation, followed by reduced activity in fat tissue, potentially combining cognitive benefits with anti-aging effects.
Possible Conflicts of Interest
None identified.
Identified Limitations
Rating Explanation
This study uses an animal model and shows correlation, not causation, limiting its applicability to humans and earning a 3 despite interesting findings in mice. The sample size is adequate for the animal model but is not very large. There is no clear conflict of interest.
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