Bidirectional Effect of Long-Term Δ9-Tetrahydrocannabinol Treatment on mTOR Activity and Metabolome
Overview
Paper Summary
This study in mice found that chronic low-dose THC treatment led to a temporary increase in brain mTOR activity, enhanced energy production, and increased synapse formation, followed by decreased mTOR activity in adipose tissue and changes in the plasma metabolome resembling some aspects of calorie restriction. Whether these effects translate to humans or persist long-term remains unclear.
Explain Like I'm Five
In old mice, low-dose THC temporarily boosted brain activity and synapse formation, followed by reduced activity in fat tissue, mimicking some benefits of calorie restriction. More research is needed to see if this applies to humans.
Possible Conflicts of Interest
None identified.
Identified Limitations
Rating Explanation
This is a well-conducted animal study providing some interesting insights into THC's effects on metabolism and brain aging. However, its reliance on a mouse model significantly limits its applicability to humans, preventing a higher rating. Further research is needed to confirm these findings in humans and investigate long-term effects.
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