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Hepatology

Liver diseases and disorders, including viral hepatitis, cirrhosis, fatty liver disease, liver cancer, liver transplantation, and the management of portal hypertension

8 papers

Papers

Transjugular Intrahepatic Portosystemic Shunt for the Management of Medically Refractory Chylous Ascites in Cirrhosis: A Single-Institution Retrospective Analysis

This retrospective analysis of only eight patients explored the use of a transjugular intrahepatic portosystemic shunt (TIPS) to treat stubborn chylous ascites (milky fluid buildup) in individuals with cirrhosis who hadn't responded to other medical treatments. The study found that TIPS led to resolution of ascites in most patients (7 out of 8), with a mean transplant-free survival of 19 months, but also noted significant complications including a 25% incidence of hepatic encephalopathy and two patient deaths.

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Hepatology Oct 01, 05:06 AM

Ketogenesis mitigates metabolic dysfunction-associated steatotic liver disease through mechanisms that extend beyond fat oxidation

In a small study of individuals with fatty liver disease, researchers found a positive correlation between the severity of liver damage and the rate of ketogenesis, a fat-burning process. Using mouse models, they showed that impaired ketogenesis reduced fat oxidation but did not always lead to more severe liver injury, hinting at a more complex role for ketogenesis beyond just burning fat.

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Hepatology Aug 15, 02:13 AM

Carbohydrate consumption and cirrhosis-related mortality: a prospective cohort study

In this prospective cohort study of 121 Iranian cirrhosis patients, higher intakes of total carbohydrates, sugar, glucose, fructose, and sucrose were associated with increased mortality risk over four years, while lactose intake was linked to lower mortality. However, the small sample size, single baseline dietary assessment, and observational design limit the ability to draw causal conclusions and generalize the findings to other populations. Further research with more robust methodology is needed to confirm these associations and explore the underlying mechanisms.

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Hepatology Jul 24, 05:55 PM

EASL CLINICAL PRACTICE GUIDELINES (CPGs) ON NON-INVASIVE TESTS FOR EVALUATION OF LIVER DISEASE SEVERITY AND PROGNOSIS- 2020 Update

The EASL guidelines recommend using non-invasive tests (NITs) to assess liver fibrosis and cirrhosis, emphasizing their role in ruling out rather than diagnosing advanced fibrosis in low-prevalence populations. Specific recommendations are provided for various liver disease etiologies, and the importance of integrating NITs with clinical acumen and other diagnostic methods is highlighted.

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Hepatology Jul 14, 05:07 PM