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Health Sciences › Medicine › Hepatology
Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study
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Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
Liver Trouble? COVID Could Make It Double! (Cirrhosis Patients at Higher Risk)
Patients with cirrhosis face a significantly higher risk of death from COVID-19 compared to those without cirrhosis (32% vs. 8%). The risk increases with cirrhosis severity and is particularly high even in younger age groups, suggesting an important interaction between liver disease and COVID-19.
Possible Conflicts of Interest
The study received funding from various organizations, including the European Association for the Study of the Liver (EASL) and the National Institutes of Health (NIH). No direct conflicts were declared by the authors, but the involvement of these organizations warrants consideration.
Identified Weaknesses
Reporting Bias
The study acknowledges potential reporting bias, as registry data may over-represent severe cases. This limits the generalizability of findings to milder or non-hospitalized patients.
Limited Scope of Patient Population
The registries primarily captured hospitalized patients, limiting insights into the course of COVID-19 in those who recovered or died without hospitalization.
Unmeasured Confounding
While the study controlled for major covariates, the possibility of unmeasured confounding (e.g., inflammation markers) cannot be excluded, potentially affecting the observed associations.
Rating Explanation
This large-scale international study provides valuable insights into COVID-19 outcomes in patients with chronic liver disease, especially cirrhosis. The study's strengths include its size, international scope, and comparison cohort. However, limitations such as reporting bias, restricted patient population, and unmeasured confounding warrant a rating of 4 rather than 5.
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File Information
Original Title:
Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: An international registry study
File Name:
r0v8380870.pdf
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File Size:
0.76 MB
Uploaded:
July 14, 2025 at 10:45 AM
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