Browse research papers in Geriatrics and Gerontology - Medicine Discover 4 academic papers with AI-powered analysis

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Geriatrics and Gerontology

Healthcare for older adults, including age-related diseases, frailty, cognitive decline, polypharmacy, long-term care, and strategies for healthy aging

4 papers in this specialization

Papers

Resveratrol Modulates the Gut Microbiota and Inflammation to Protect Against Diabetic Nephropathy in Mice

Resveratrol treatment improved renal function and reduced inflammation in diabetic mice by altering their gut microbiome and intestinal health. Fecal transplants from resveratrol-treated mice to diabetic mice replicated these benefits, supporting a gut-kidney connection in diabetic kidney disease.

Alpha-synuclein-induced mitochondrial dysfunction is mediated via a sirtuin 3-dependent pathway

This study found that asyn oligomers associate with mitochondria, leading to decreased SIRT3 levels and mitochondrial dysfunction. Activating SIRT3 with an AMPK agonist rescues these defects, suggesting a potential therapeutic avenue for Parkinson's disease.

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s13024-019-0349-x.pdf

Jul 14, 10:45 AM

NAD+ repletion rescues female fertility during reproductive aging

This study found that declining NAD+ levels are associated with age-related decline in oocyte quality and female fertility in mice. Treatment with NMN, an NAD+ precursor, restored oocyte quality, improved embryo development, and increased live birth rates in aged mice. Similar effects were seen in aged Sirt2Tg/+ mice, though Sirt2 deletion alone did not impair oocyte quality in younger animals, suggesting a potential role for this enzyme.

Medication errors in a health care facility in southern Saudi Arabia

This study investigated medication errors at Aseer Central Hospital in Saudi Arabia. The most common prescribing errors were medication duplication (31.2%) and missing patient identifying information (25%), mostly occurring in inpatient prescriptions. Dispensing errors were less frequent (0.9%).