Healthcare for older adults, including age-related diseases, frailty, cognitive decline, polypharmacy, long-term care, and strategies for healthy aging
8 papersThis comprehensive review synthesizes existing research, predominantly from animal models, demonstrating that regular physical activity can mitigate all 14 hallmarks of biological aging. The findings suggest exercise is a promising non-pharmacological strategy to promote healthy aging, but emphasize the critical need for more human studies to confirm and extend these benefits.
This 20-year longitudinal study of nearly 3,000 older adults found that meal timing shifts with age, with breakfast and dinner trending later. Later breakfast time was associated with increased morbidity and a higher risk of mortality, suggesting it may be a simple health marker in older adults. The study also explored the relationship between meal timing, genetic predispositions, and health behaviors.
In a 20-year study of nearly 3000 older adults, later breakfast time was associated with increased mortality risk, especially in those with health issues. Later breakfast may be an indicator of broader health decline, and this study emphasizes the importance of maintaining healthy eating habits throughout life. The study is limited by its reliance on self-reported data and potential for unmeasured confounding.
This review emphasizes the importance of personalized care for older adults with chronic kidney disease, considering factors like frailty, other health conditions, and patient preferences in treatment decisions. It suggests that for some older adults, a conservative approach focusing on quality of life may be preferable to dialysis. The review highlights the need for shared decision-making and clear communication.
Resveratrol treatment improved renal function and reduced inflammation in diabetic mice by altering their gut microbiome and intestinal health. Fecal transplants from resveratrol-treated mice to diabetic mice replicated these benefits, supporting a gut-kidney connection in diabetic kidney disease.
This study found that asyn oligomers associate with mitochondria, leading to decreased SIRT3 levels and mitochondrial dysfunction. Activating SIRT3 with an AMPK agonist rescues these defects, suggesting a potential therapeutic avenue for Parkinson's disease.
This study found that declining NAD+ levels are associated with age-related decline in oocyte quality and female fertility in mice. Treatment with NMN, an NAD+ precursor, restored oocyte quality, improved embryo development, and increased live birth rates in aged mice. Similar effects were seen in aged Sirt2Tg/+ mice, though Sirt2 deletion alone did not impair oocyte quality in younger animals, suggesting a potential role for this enzyme.
This study investigated medication errors at Aseer Central Hospital in Saudi Arabia. The most common prescribing errors were medication duplication (31.2%) and missing patient identifying information (25%), mostly occurring in inpatient prescriptions. Dispensing errors were less frequent (0.9%).