Exercise attenuates the hallmarks of aging: Novel perspectives

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Identified Weaknesses

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Paper Summary

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Exercise Fights Aging, But Most Proof Is Still in Animals!

This comprehensive review synthesizes existing research, predominantly from animal models, demonstrating that regular physical activity can mitigate all 14 hallmarks of biological aging. The findings suggest exercise is a promising non-pharmacological strategy to promote healthy aging, but emphasize the critical need for more human studies to confirm and extend these benefits.

Possible Conflicts of Interest

None identified. The authors explicitly state they have no competing interests.

Identified Weaknesses

Predominant Reliance on Animal Studies

The review primarily synthesizes findings from animal models (e.g., mice, rats, Drosophila) when discussing how exercise attenuates hallmarks of aging. While these models provide mechanistic insights, directly applying these 'novel perspectives' to human health requires significant further validation in human subjects. The paper itself acknowledges this as a limitation.

Lack of Specific Dose-Response Guidance for Humans

The review notes that further research is needed to define optimal exercise parameters (modality, intensity, duration) and identify effective minimum doses and upper safety thresholds for older adults. This indicates that practical, personalized exercise prescriptions based on the reviewed evidence are still under development and not yet fully established.

Broad Scope of Review

While comprehensive in covering all 14 hallmarks of aging, the broad scope may lead to less in-depth analysis on specific molecular mechanisms or limitations within each hallmark area, compared to more focused reviews.

Pre-Proof Status

The document is a 'Journal Pre-proof,' meaning it has undergone enhancements after acceptance but is not yet the definitive Version of Record. It will undergo additional copyediting, typesetting, and review, which implies that minor errors or changes could still occur before final publication.

Rating Explanation

The paper provides a very comprehensive and well-structured review of how exercise impacts all 14 hallmarks of aging, synthesizing a vast amount of literature. However, its primary limitation, as acknowledged by the authors, is the heavy reliance on findings from animal studies to support claims about human aging, which significantly reduces its direct applicability to humans and warrants a maximum rating of 3.

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