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Immunology and Microbiology
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Immunology
Immunology
The study of immune systems in all organisms, including innate and adaptive immunity, immunological disorders, vaccines, transplantation immunology, and therapeutic immunology approaches
7 papers in this specialization
Papers
The source of dietary fat influences anti-tumour immunity in obese mice
In obese mice, the type of dietary fat influences tumor growth and anti-tumor immunity. Butter-based high-fat diets accelerate tumor growth and impair immune cell function, while palm oil-based diets protect against these effects, likely by altering lipid metabolism and acylcarnitine levels. While promising, this research was conducted on mice and may not directly translate to humans.
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s42255-025-01330-w.pdf
Jul 31, 06:35 PM
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer
This study explored the spatial organization of the tumor microenvironment (TME) in non-small cell lung cancer (NSCLC) using imaging mass cytometry and genomic data from the TRACERx 100 cohort. Researchers identified four TME subtypes, including a neutrophil-rich type associated with poorer clinical outcomes and metastasis. The study also found associations between spatial TME features, neoantigen burden, and immune evasion mechanisms.
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1018.pdf
Jul 21, 10:21 AM
The mitochondrial anti-viral protein MAVS associates with NLRP3 and regulates its inflammasome activity
This study, primarily in cells and mice, finds that the mitochondrial antiviral protein MAVS interacts with NLRP3, a key component of the inflammasome, and regulates its activity, particularly in response to Sendai virus infection. This interaction appears to facilitate NLRP3 oligomerization and subsequent caspase-1 activation, suggesting a new mechanism for inflammasome regulation in the context of viral infection.
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Park et al. - 2013 - The mitochondrial anti-viral protein MAVS associates with NLRP3 and regulates its inflammasome activ.pdf
Jul 19, 04:25 PM
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
This study found that patients with severe COVID-19 have an abundance of pro-inflammatory macrophages in their lungs, while moderate cases show increased expansion of certain CD8+ T cells. This suggests different immune mechanisms are at play depending on the severity of the disease, potentially offering clues for targeted therapies.
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s41591-020-0901-9.pdf
Jul 14, 10:31 AM
TLR7 gain-of-function genetic variation causes human lupus
A de novo TLR7 gain-of-function variant was identified in a child with severe lupus and validated in mice. This variant increases TLR7's affinity for guanosine, leading to enhanced signaling, aberrant B cell survival, and autoimmunity, paving the way for TLR7 or MyD88 inhibition therapies.
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s41586-022-04642-z.pdf
Jul 14, 10:31 AM
Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer
A personalized mRNA neoantigen vaccine, combined with standard therapies, safely stimulated T-cell responses in half of the patients with resectable pancreatic cancer. These vaccine-expanded T cells were durable, persisted despite chemotherapy, and showed evidence of potential micrometastasis eradication in one patient, correlating with delayed disease recurrence.
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s41586-023-06063-y.pdf
Jul 14, 10:31 AM
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
The study found that CD4+ T cells exist on a continuum of effectorness, from naive to effector memory, which influences their response to cytokines. Memory T cells, unlike naive T cells, can't become Th2 cells and actually develop Th17-like characteristics when exposed to iTreg-polarizing conditions.
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s41467-020-15543-y.pdf
Jul 14, 10:31 AM
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