ME/CFS and PASC Patient-Derived Immunoglobulin Complexes Disrupt Mitochondrial Function and Alter Inflammatory Marker Secretion

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Conflicts of Interest

Identified Weaknesses

Rating Explanation

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Paper Summary

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Antibodies from ME/CFS Patients Mess with Cell Energy: A Lab Study

This in vitro study found that antibodies from ME/CFS patients caused mitochondrial fragmentation and altered energy production in human cells, potentially contributing to some symptoms of the disease. However, this study was conducted in vitro with limited sample sizes and the exact mechanism remains unclear, requiring further investigation to confirm these findings and explore potential treatments.

Possible Conflicts of Interest

None identified.

Identified Weaknesses

Small sample size

The sample sizes for both ME/CFS and control groups were relatively small, limiting the generalizability of the findings.

In vitro study

The study was conducted in vitro, and it is unclear whether the observed effects would translate to the human body.

Lack of specific autoantibody identification

The researchers did not identify specific autoantibodies responsible for the observed mitochondrial effects.

Technical limitations

The researchers acknowledge pronounced inter-plate variability in the Seahorse assay, which makes it difficult to draw firm conclusions.

Rating Explanation

This is an interesting in vitro study with some potential implications for ME/CFS research, but it has several limitations, including a small sample size and the lack of in vivo validation. Therefore, it receives a rating of 3.

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