RNA N-glycosylation enables immune evasion and homeostatic efferocytosis

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Conflicts of Interest

Identified Weaknesses

Rating Explanation

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Paper Summary

Paperzilla title

Modified RNA Helps Cells Hide From the Immune System (in a Dish)

This study found that N-glycosylation of RNA can help cells evade immune responses and encourages a cleanup process called efferocytosis. These findings are based on in vitro and ex vivo experiments, and further research is needed to determine their relevance in living organisms.

Possible Conflicts of Interest

None identified

Identified Weaknesses

Lacks in vivo studies

The experiments were performed in vitro (cells) and ex vivo (tissues). The relevance of these findings to actual disease in living organisms is unclear.

Blots are not quantified

The blots do not include quantitative analysis, leaving open the possibility of subjective interpretation. More robust analysis should include quantifications, normalizations, and proper statistics.

Rating Explanation

The study presents interesting in vitro findings, however, the lack of in vivo validation significantly limits its impact and generalizability. Thus, a rating of 3 is appropriate.

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