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Life Sciences › Immunology and Microbiology › Immunology
The source of dietary fat influences anti-tumour immunity in obese mice
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Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
Butter Makes Tumors Grow Faster in Obese Mice, But Palm Oil Doesn't: A Dietary Fat Face-Off
In obese mice, the type of dietary fat influences tumor growth and anti-tumor immunity. Butter-based high-fat diets accelerate tumor growth and impair immune cell function, while palm oil-based diets protect against these effects, likely by altering lipid metabolism and acylcarnitine levels. While promising, this research was conducted on mice and may not directly translate to humans.
Possible Conflicts of Interest
L.L. has disclosed affiliations with several biotech/pharmaceutical companies. M.H. is affiliated with the MD Anderson Allison Institute. These were reviewed and managed by their respective institutions.
Identified Weaknesses
Limited generalizability to human diets
The HFDs used in this study were derived from single fat sources, which is not representative of a typical human diet. It is difficult to draw conclusions about the impact of changes in human consumption of specific fats based on this study design.
Limited tumor models
The study primarily focuses on B16 melanoma and includes limited testing on other tumor models. The effect of dietary fat source may vary across different tumor types, and further research is needed to explore this.
Incomplete mechanistic understanding
The study doesn't fully elucidate the mechanism responsible for CAR18:0 enrichment in butter-HFD or definitively prove it's solely responsible for CD8 T cell dysfunction. Other metabolic factors may also contribute.
Potential confounding due to Nnt mutation
The use of C57BL/6J mice with the Nnt mutation may limit the translational relevance of the findings related to mitochondrial function, as this mutation is not present in humans or wild-type mice.
Rating Explanation
This study uses a robust methodology with in vivo and in vitro experiments and proteomic and metabolomic analyses to investigate a clinically relevant question. The findings are compelling, but the limitations regarding generalizability to human diets and the use of a single-gene mutation mouse model warrant a slightly lower rating.
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File Information
Original Title:
The source of dietary fat influences anti-tumour immunity in obese mice
File Name:
s42255-025-01330-w.pdf
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File Size:
11.70 MB
Uploaded:
July 31, 2025 at 06:35 PM
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