High resolution diffusion tensor imaging of the human cortex reveals non-linear trajectories over the healthy lifespan
This study used high-resolution diffusion tensor imaging (DTI) to track changes in the human cortex across the lifespan (ages 5-74). Cortical thickness followed the expected pattern of decreasing with age, while other DTI measures like fractional anisotropy and diffusivity followed U-shaped trajectories, with minimum values in adulthood. Radiality, a measure specific to cortical diffusion, showed a unique cubic trajectory, decreasing in both childhood and old age.