Browse research papers in Developmental Neuroscience - Neuroscience Discover 5 academic papers with AI-powered analysis

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Developmental Neuroscience

Development of the nervous system, including neurogenesis, axon guidance, synapse formation, neural plasticity, and developmental disorders of the nervous system

5 papers in this specialization

Papers

Automatic Facial Recognition of Williams-Beuren Syndrome Based on Deep Convolutional Neural Networks

Deep convolutional neural networks, particularly VGG-19, achieved high accuracy (over 90%) in identifying Williams-Beuren Syndrome (WBS) based on facial photographs, exceeding the performance of human experts. This automated approach could facilitate early diagnosis and improve clinical workflow, especially in regions with limited access to genetic testing.

Iron overload contributes to general anaesthesia-induced neurotoxicity and cognitive deficits

General anesthesia (GA) disrupts iron homeostasis in the brain, leading to iron overload and triggering ferroptosis, a form of iron-dependent cell death. Chelating excess iron with deferiprone or blocking iron uptake through DMT1 can prevent neuronal damage and improve cognitive outcomes after GA exposure, indicating potential therapeutic strategies for GA-induced cognitive deficits.

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s12974-020-01777-6.pdf

Jul 14, 11:18 AM

Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation

This study found that SIRT3 expression decreases in the hippocampus of aged mice after anesthesia and surgery, leading to cognitive decline. Overexpression of SIRT3 was shown to protect against this cognitive decline by suppressing neuroinflammation and improving synaptic plasticity.

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s12974-021-02089-z.pdf

Jul 14, 11:18 AM

Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca²+/calpain might contribute to postoperative cognitive dysfunction in aging mice

Anesthesia and surgery can trigger neuroinflammation, leading to overactivation of NMDARs and calpain, which in turn messes with BDNF/TrkB signaling, causing memory problems in older mice. Luckily, blocking NMDARs or calpain seemed to protect the mice's brains and memories!

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s12974-019-1695-x.pdf

Jul 14, 11:18 AM

Generation of Vascularized Brain Organoids to Study Neurovascular Interactions

Researchers created a "fusion" brain organoid model with integrated blood vessels and microglia, the brain's immune cells. These vascularized organoids exhibited enhanced neural progenitor proliferation and developed functional blood-brain barrier properties, offering a promising new tool for studying brain development and disease.

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2022.01.04.474960.full.pdf

Jul 14, 11:18 AM