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Life Sciences › Neuroscience › Developmental Neuroscience
Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation
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Conflicts of Interest
Identified Weaknesses
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Paper Summary
Paperzilla title
Boosting SIRT3 in the brain may help protect against post-surgery brain fog in older mice
This study found that SIRT3 expression decreases in the hippocampus of aged mice after anesthesia and surgery, leading to cognitive decline. Overexpression of SIRT3 was shown to protect against this cognitive decline by suppressing neuroinflammation and improving synaptic plasticity.
Possible Conflicts of Interest
None identified
Identified Weaknesses
Limited scope and generalizability
The study acknowledges limitations such as focusing solely on early postoperative cognitive function and not long-term outcomes, using only one type of anesthesia and surgical procedure, the indirect correlation of mice behavioral tests with human cognitive function, measuring total SOD activity instead of specific types, and not fully excluding other potential molecules involved in SIRT3-mediated POCD.
Rating Explanation
This study provides valuable insights into the role of SIRT3 in POCD and its potential as a therapeutic target. The methodology is generally sound, but the limitations regarding the scope of the study and the use of an animal model prevent a higher rating.
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Original Title:
Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation
File Name:
s12974-021-02089-z.pdf
[download]
File Size:
10.24 MB
Uploaded:
July 14, 2025 at 11:18 AM
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