High resolution diffusion tensor imaging of the human cortex reveals non-linear trajectories over the healthy lifespan
Overview
Paper Summary
This study used high-resolution diffusion tensor imaging (DTI) to track changes in the human cortex across the lifespan (ages 5-74). Cortical thickness followed the expected pattern of decreasing with age, while other DTI measures like fractional anisotropy and diffusivity followed U-shaped trajectories, with minimum values in adulthood. Radiality, a measure specific to cortical diffusion, showed a unique cubic trajectory, decreasing in both childhood and old age.
Explain Like I'm Five
As brains grow older, some parts get thinner while others change how water moves through them. This study measured these changes in lots of people from different ages.
Possible Conflicts of Interest
None identified.
Identified Limitations
Rating Explanation
This is a well-designed study with a large sample size and a good methodology, investigating an important topic. The findings are novel and contribute to the understanding of age-related changes in brain microstructure. Although there are limitations related to DTI resolution and potential partial volume effects, these are acknowledged by the authors. Overall, it's a strong study with minor limitations, deserving a rating of 4.
Good to know
This is the Starter analysis. Paperzilla Pro fact-checks every citation, researches author backgrounds and funding sources, and uses advanced AI reasoning for more thorough insights.
Explore Pro →