Brain-to-brain coupling during handholding is associated with pain reduction
This study found that hand-holding between romantic partners during a pain experiment increased brain-to-brain coupling in the alpha-mu frequency band, primarily between the central brain regions of the person experiencing pain and the right hemisphere of their partner. This coupling correlated with both pain reduction in the target and empathic accuracy in the observer. However, it's important to note that the study has limitations due to sample size and demographics, limited EEG spatial resolution, the correlational nature of the data, and the potential confound of the sound cue used in the experiment.
goldstein-et-al-brain-to-brain-coupling-during-handholding-is-associated-with-pain-reduction.pdf