A brain-wide map of neural activity during complex behaviour

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Conflicts of Interest

Identified Weaknesses

Rating Explanation

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Paper Summary

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Mouse Brain on a Wheel: Mapping Neural Activity During Decisions

This study used Neuropixels probes to record from over 600,000 neurons in mice performing a decision-making task. They found brain-wide neural correlates of various task elements, including visual stimuli, choices, feedback, and movement, with varying degrees of representation across brain regions. Some regions responded strongly to feedback and movement, while others showed stronger selectivity for visual stimuli or choices.

Possible Conflicts of Interest

None identified

Identified Weaknesses

Animal model

The findings are from mice and may not generalize to humans.

Limited generalizability

While a large dataset, it is still limited to one species and task.

Confounding motor activity

It is difficult to isolate cognitive processes from motor actions.

Rating Explanation

Strong methodology with a large dataset and rigorous analyses, but limited generalizability due to the animal model.

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