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Hematology

Hematology

Blood disorders and diseases, including anemia, bleeding disorders, thrombosis, hematologic malignancies, transfusion medicine, and stem cell transplantation
9 papers in this specialization

Paperzilla Papers in Hematology

Assessment and treatment of frail patients living with multiple myeloma. A guideline on behalf of the UK Myeloma Research Alliance Frailty Group

This guideline reviews the assessment and treatment of frail multiple myeloma (MM) patients, emphasizing the importance of frailty assessment tools like the IMWG-FS and UK-MRP. It recommends risk-adapted treatment approaches, including dose modifications and supportive care strategies, to optimize outcomes in this vulnerable group.
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paper_1269.pdf
Sep 08, 06:18 PM

Absolute and Functional Iron Deficiency in the US, 2017-2020

This cross-sectional study analyzed data from the National Health and Nutritional Examination Survey (NHANES) and found that 14% of US adults have absolute iron deficiency and 15% have functional iron deficiency. Iron supplement use was low among adults with iron deficiency, ranging from 22% to 35% in women and 12% to 18% in men, depending on age.
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paper_1267.pdf
Sep 08, 05:11 PM

A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles

This small human study (n=12) suggests that a single dose of nattokinase, an enzyme from fermented soybeans, may improve blood clot breakdown and reduce clotting. The changes observed were all within the normal range and more research with larger sample size is needed.
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paper_1240.pdf
Sep 07, 07:29 PM

Unexpected CD5+ B Cell Lymphocytosis during SARS-CoV-2 Infection: Relevance for the Pathophysiology of Chronic Lymphocytic Leukemia

This paper describes the unusual phenomenon of lymphocytosis (increased white blood cell counts) observed in some patients with chronic lymphocytic leukemia (CLL) during SARS-CoV-2 infection, contrasting with the typical lymphopenia seen in most COVID-19 patients. The authors speculate on possible mechanisms, including direct activation of CLL cells by the virus or indirect activation via immune responses, but further research is needed to confirm these hypotheses and determine the long-term impact on CLL progression.
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paper_1042.pdf
Sep 03, 01:03 PM

Red blood cell deformability is diminished in patients with Chronic Fatigue Syndrome

In a small study, red blood cells from chronic fatigue syndrome (CFS) patients were found to be less deformable than those from healthy controls using a microfluidic device. This stiffness may contribute to symptoms like pain and fatigue by impairing microcirculation, but larger, longitudinal studies are needed to confirm these findings and explore underlying mechanisms. The study is further limited by its cross-sectional design and potential confounding from patient medication use.
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paper_312.pdf
Aug 17, 08:32 PM

Detection of Long COVID Microclots using Pulsed Speckle Contrast Optical Spectroscopy

This study investigated a new method for detecting microclots, which are thought to be linked to long COVID, using lasers. While the method was able to distinguish different clot concentrations in simpler test fluids, it faced challenges in whole blood due to interference from blood cells. Further research is needed to overcome these limitations and confirm findings with patient samples.
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paper_162.pdf
Aug 09, 08:45 PM

2021 Thalassaemia International Federation Guidelines for the Management of Transfusion-dependent Thalassemia

The guidelines provide updated recommendations for managing transfusion-dependent thalassemia (TDT), emphasizing regular blood transfusions, iron chelation therapy, and monitoring/management of various complications. They also highlight the importance of a multidisciplinary approach, patient-centered care, and addressing psychosocial aspects for optimizing quality of life in TDT patients.
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2021_Thalassaemia_International_Federation.6.pdf
Jul 14, 05:17 PM

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

Therapeutic-dose heparin increased the probability of survival to hospital discharge with reduced need for organ support in moderately ill COVID-19 patients. While major bleeding was more frequent in the heparin group, the benefits in terms of organ support-free days were substantial enough to warrant consideration of this treatment strategy.
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238101.pdf
Jul 14, 05:12 PM

Burden of anemia and its underlying causes in 204 countries and territories, 1990–2019: results from the Global Burden of Disease Study 2019

Anemia affects around 1.8 billion people globally and caused 50.3 million years lived with disability (YLDs) in 2019. While age-standardized rates of anemia have decreased since 1990, the absolute numbers have increased, likely due to population growth and aging. Dietary iron deficiency remains the primary cause of anemia worldwide.
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s13045-021-01202-2.pdf
Jul 14, 10:54 AM
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