Browse research papers in Molecular Biology - Biochemistry, Genetics and Molecular Biology Discover 4 academic papers with AI-powered analysis

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Biochemistry, Genetics and Molecular Biology

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Molecular Biology

The molecular mechanisms of biological processes, focusing on DNA, RNA, and protein interactions, gene expression, signal transduction, molecular techniques, and the molecular basis of cellular function

4 papers in this specialization

Papers

Bacterial two-hybrid systems evolved: Innovations for protein-protein interaction research

This review summarizes different versions of the bacterial two-hybrid (B2H) assay, a method used to study how proteins interact with each other in bacteria. It covers general considerations for using the technique, discusses several variations of the method, and compares it to other common methods for detecting protein interactions.

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richardson-pascal-bacterial-two-hybrid-systems-evolved-innovations-for-protein-protein-interaction-research.pdf

Aug 01, 07:38 PM

Calorie restriction and calorie-restriction mimetics activate chaperone-mediated autophagy

Calorie restriction (CR) and calorie-restriction mimetics (CRMs) activate chaperone-mediated autophagy (CMA), a cellular recycling process. This activation is due to increased stability of LAMP2A, the CMA receptor, at the lysosome membrane, and is required for the protective effects of CRMs against high-carbohydrate diets in mice.

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jafari-et-al-calorie-restriction-and-calorie-restriction-mimetics-activate-chaperone-mediated-autophagy.pdf

Jul 18, 10:02 AM

Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease

This study found that increased mitochondrial calcium levels are associated with amyloid plaques and neuronal death in a mouse model of Alzheimer's disease. Soluble Aβ oligomers directly increase mitochondrial calcium in neurons, an effect dependent on the mitochondrial calcium uniporter.

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s41467-020-16074-2.pdf

Jul 14, 10:33 AM

AiZynthFinder: a fast, robust and flexible open-source software for retrosynthetic planning

This paper introduces AiZynthFinder, an open-source software for retrosynthetic planning based on Monte Carlo tree search and a neural network policy. The software is designed for speed and flexibility and has been shown to generate plausible synthetic routes, although comprehensive benchmarking and experimental validation are areas for future development.

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s13321-020-00472-1.pdf

Jul 14, 10:33 AM