AiZynthFinder: a fast, robust and flexible open-source software for retrosynthetic planning
Overview
Paper Summary
This paper introduces AiZynthFinder, an open-source software for retrosynthetic planning based on Monte Carlo tree search and a neural network policy. The software is designed for speed and flexibility and has been shown to generate plausible synthetic routes, although comprehensive benchmarking and experimental validation are areas for future development.
Explain Like I'm Five
Scientists found a new computer program that's like a smart helper. It quickly figures out how to make complicated chemicals from simpler parts, like finding the best recipe to build a big toy from small blocks.
Possible Conflicts of Interest
The authors disclose affiliations with AstraZeneca and the University of Bern. While the software itself is open-source, the potential for bias in choosing comparisons or emphasizing certain aspects cannot be ruled out.
Identified Limitations
Rating Explanation
This paper presents a valuable open-source tool for retrosynthetic planning. While the core algorithm shows promise and the open-source nature fosters community development, the limited comparison with other tools and the reliance on commercial data prevent a full 5-star rating.
Good to know
This is the Starter analysis. Paperzilla Pro fact-checks every citation, researches author backgrounds and funding sources, and uses advanced AI reasoning for more thorough insights.
Explore Pro →