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Biochemistry, Genetics and Molecular Biology

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Endocrinology

The study of hormones and the endocrine system, including hormone synthesis, secretion, and action, endocrine disorders, neuroendocrinology, and the regulation of metabolism, growth, and reproduction

5 papers in this specialization

Paperzilla Papers in Endocrinology

Muscle-Organ Crosstalk: The Emerging Roles of Myokines

This review discusses how muscles release proteins called myokines during exercise, which act as messengers to other parts of the body like the brain, fat, and bones, affecting various processes like metabolism, cognition, and even tumor growth. While the exact function of many identified myokines remains unknown, the paper highlights their potential as biomarkers for exercise prescription and therapeutic targets. Much of the research is based on animal models, so more research is needed to confirm these effects in humans.

The effects of exercise intensity on the cortisol response to a subsequent acute psychosocial stressor

This study found that vigorous exercise dampened the cortisol response to a later psychosocial stress task in a sample of young men, whereas light and moderate exercise did not. This suggests a dose-response relationship between exercise intensity and the body's stress response to future stressful events, potentially through a glucocorticoid negative feedback loop.

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1-s2.0-S0306453021002109-main.pdf

Aug 03, 04:49 PM

Analysis of Acanthamoeba genotypes from public freshwater sources in Thailand reveals a new genotype, T23 Acanthamoeba bangkokensis sp. nov.

A survey of public freshwater sources in Thailand identified a new genotype of Acanthamoeba, named T23 Acanthamoeba bangkokensis sp. nov. Genotype T4 was the most common, and evidence suggested purifying selection and intragenic recombination play a role in the evolution of the 18S rRNA gene in this genus.

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s41598-021-96690-0.pdf

Jul 14, 11:20 AM

Population genomics and antimicrobial resistance in Corynebacterium diphtheriae

This study found widespread acquired resistance to penicillin among C. diphtheriae isolates and identified a novel penicillin-binding protein gene (pbp2m) associated with resistance. This gene is located on a large multidrug resistance plasmid and its expression in C. glutamicum demonstrated its effect against several beta-lactams, potentially impacting treatment strategies for diphtheria.

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s13073-020-00805-7.pdf

Jul 14, 11:20 AM

Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium reprograms macrophage metabolism to enhance its own intracellular replication and virulence. It does this by increasing glycolysis, suppressing serine synthesis (via SopE2 effector), and utilizing accumulated 3PG as a carbon source, while also sensing pyruvate and lactate to activate virulence genes (SPI-2) via the CreBC system.

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s41467-021-21186-4.pdf

Jul 14, 11:20 AM