Muscle-Organ Crosstalk: The Emerging Roles of Myokines
Overview
Paper Summary
This review discusses how muscles release proteins called myokines during exercise, which act as messengers to other parts of the body like the brain, fat, and bones, affecting various processes like metabolism, cognition, and even tumor growth. While the exact function of many identified myokines remains unknown, the paper highlights their potential as biomarkers for exercise prescription and therapeutic targets. Much of the research is based on animal models, so more research is needed to confirm these effects in humans.
Explain Like I'm Five
When you exercise, your muscles release special proteins called myokines that act like messengers, talking to other parts of your body like your brain, fat, and bones. These myokines tell these other parts of your body to do things that are good for you.
Possible Conflicts of Interest
None identified
Identified Limitations
Rating Explanation
This review paper provides a comprehensive overview of the emerging field of myokines and their roles in inter-organ communication. It synthesizes a large body of research and presents a compelling narrative for the importance of exercise in overall health. Although many of the cited studies are preclinical, which limits direct translation to human applications, the paper serves as a valuable resource for researchers and clinicians. The lack of in-depth discussion about potential negative effects slightly lowers the rating.
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