Browse research papers in Biochemistry - Biochemistry, Genetics and Molecular Biology Discover 4 academic papers with AI-powered analysis

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Biochemistry, Genetics and Molecular Biology

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Biochemistry

The chemical processes and substances within living organisms, studying proteins, nucleic acids, carbohydrates, lipids, and their interactions, including enzyme function, metabolic pathways, and molecular mechanisms of life

4 papers in this specialization

Papers

Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators

SARS-CoV-2 infection increases lipid droplet (LD) formation in human cells by modulating lipid metabolism. Inhibiting LD formation with a DGAT-1 inhibitor reduces viral replication, cell death, and inflammatory mediator production, suggesting LDs play a role in viral replication and host immune dysregulation. This highlights a potential therapeutic avenue for COVID-19 through targeting lipid metabolic pathways.

A COX-2/sEH dual inhibitor PTUPB alleviates lipopolysaccharide-induced acute lung injury in mice by inhibiting NLRP3 inflammasome activation

This study found that a dual COX-2 and sEH inhibitor, PTUPB, alleviates LPS-induced acute lung injury in mice by inhibiting the activation of the NLRP3 inflammasome. The dysregulation of CYPs/COX-2 metabolism of arachidonic acid contributes to the uncontrolled inflammatory response in ALI, making it a potential therapeutic target.

Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

This study reveals that inhibiting the serine synthesis pathway (SSP) using a drug called PH755, combined with a diet low in serine and glycine, can effectively curb cancer growth. This combo approach works even against tumors that resist either the diet or drug alone, highlighting its potential as a promising cancer therapy.

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s41467-020-20223-y.pdf

Jul 14, 11:12 AM

SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells

This study reports that high overexpression of the cystine transporter SLC7A11 increases cancer cell death under high H2O2 treatment, contrary to its protective role in moderate oxidative stress. This is due to excessive cystine uptake leading to intracellular disulfide buildup, NADPH depletion, and disulfidptosis, revealing a context-dependent role for SLC7A11 in cancer biology.

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s41467-023-39401-9.pdf

Jul 14, 11:12 AM