Amyloidogenesis of SARS-CoV-2 Spike Protein

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Paper Summary

Conflicts of Interest

Identified Weaknesses

Rating Explanation

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Paper Summary

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Test Tube Troubles: Can the Coronavirus Spike Protein Turn Sticky?

This in vitro study suggests that parts of the SARS-CoV-2 spike protein can form amyloid-like fibrils, especially when exposed to the enzyme neutrophil elastase (NE). These fibrils could contribute to blood clotting issues seen in COVID-19. More research is needed to confirm these findings in living organisms and to determine their clinical significance.

Possible Conflicts of Interest

None identified

Identified Weaknesses

In vitro study

The experiments were conducted in vitro, meaning 'in glass' or outside a living organism. This means the findings might not fully reflect what happens in the complex environment of the human body.

Needs further in vivo validation

The study suggests a possible mechanism, but further research is needed to confirm if this process actually occurs in people infected with SARS-CoV-2.

Limited scope

The study primarily focuses on one enzyme (NE) and one spike protein fragment. Other enzymes and fragments might also play a role in amyloid formation.

Rating Explanation

This is an interesting in vitro study suggesting a potential mechanism for some of the long-term effects of COVID-19. However, it is crucial to remember that these findings are preliminary and need further investigation in living organisms. The rating is adjusted down to 3 due to the inherent limitations of an in vitro study.

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