Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy
Overview
Paper Summary
This study reveals that inhibiting the serine synthesis pathway (SSP) using a drug called PH755, combined with a diet low in serine and glycine, can effectively curb cancer growth. This combo approach works even against tumors that resist either the diet or drug alone, highlighting its potential as a promising cancer therapy.
Explain Like I'm Five
Scientists found that if you give cancer cells less special food and also block their own kitchen that makes it, it's really hard for them to grow, even tricky ones.
Possible Conflicts of Interest
One author is affiliated with Raze Therapeutics, Inc., which may have a commercial interest in the development of PHGDH inhibitors.
Identified Limitations
Rating Explanation
This study presents strong evidence for the therapeutic potential of combining a serine/glycine restricted diet with PHGDH inhibition in cancer. The research is well-designed, employs multiple in vitro and in vivo models, and provides mechanistic insights. Despite some limitations, such as the difference in ATF-4 response between in vitro and in vivo settings and the reliance on xenograft models, the overall quality and impact of the study merit a rating of 4.
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