Browse research papers in Aging - Biochemistry, Genetics and Molecular Biology Discover 7 academic papers with AI-powered analysis

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Biochemistry, Genetics and Molecular Biology

Aging

The biological study of aging processes at molecular, cellular, and organismal levels, including mechanisms of senescence, age-related diseases, longevity, regenerative medicine, and interventions to promote healthy aging

7 papers in this specialization

Paperzilla Papers in Aging

Stochasticity in dietary restriction-mediated lifespan outcomes in Drosophila

This study on fruit flies found that genetic background and random variation ("stochasticity") were the main factors determining lifespan, overshadowing the effects of dietary restriction, which had a minor impact overall. Dietary restriction did not universally prolong lifespan, and its effects were not consistent across different cohorts.

Nonlinear dynamics of multi-omics profiles during human aging

This longitudinal multi-omics study of 108 people found that aging-related molecular changes happen in nonlinear waves, with big shifts around ages 44 and 60. These shifts affect various systems, like immunity and metabolism, and correlate with increased risks of diseases like CVD and T2D.

Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging

This study used a small sample of aged bone marrow samples in a simulated space environment to examine stem cell aging. It found evidence suggesting accelerated stem cell aging in space, including changes in cell cycle, gene expression, and mutations. However, the limitations of the study, including short duration, small sample size, in vitro nature, and the use of simulated microgravity/radiation, prevent definite conclusions about stem cell aging in actual spaceflight.

Shorter Men Live Longer: Association of Height with Longevity and FOXO3 Genotype in American Men of Japanese Ancestry

In a 40-year study of over 8,000 American men of Japanese ancestry, shorter stature was associated with increased lifespan. This may be related to height's association with fasting insulin levels and FOXO3 genotype, a gene linked to longevity and insulin signaling. However, it remains difficult to rule out other confounders like childhood nutrition, which may impact both height and lifespan.

CeMbio - The Caenorhabditis elegans Microbiome Resource

This study introduces CeMbio, a defined community of 12 bacterial strains representing the core microbiome of C. elegans. All strains effectively colonize the worm gut, both individually and as a community, with varying colonization dynamics depending on the strain, environment, and time. Furthermore, the CeMbio community impacts C. elegans developmental rates, showcasing its potential to influence host physiology.

Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans

This study found that lysosomes in the worm C. elegans lose their efficiency with age, impacting their ability to break down cellular waste. However, in long-lived mutant worms, lysosome activity is better maintained, and boosting lysosome function is essential for the long lifespan of these mutants.

Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK Biobank participants

Adults with "older" biological ages based on blood chemistry were more likely to have depression and anxiety at baseline and over an 8.7-year follow-up. These relationships remained after considering genetic risk for these conditions.

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Jul 14, 11:19 AM