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Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging
CeMbio - The Caenorhabditis elegans Microbiome Resource
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Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
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Paper Summary
Paperzilla title
Worms' Got Talent: Introducing CeMbio, the C. Elegans Microbiome Dream Team!
This study introduces CeMbio, a defined community of 12 bacterial strains representing the core microbiome of C. elegans. All strains effectively colonize the worm gut, both individually and as a community, with varying colonization dynamics depending on the strain, environment, and time. Furthermore, the CeMbio community impacts C. elegans developmental rates, showcasing its potential to influence host physiology.
Possible Conflicts of Interest
None identified
Identified Weaknesses
Limited ecological context
The study focuses on in vitro and in vivo colonization assays, which might not fully reflect the complexity of real-world interactions within the host or its natural environment.
Limited functional analysis
While the study provides genomic and metabolic information, it lacks deeper exploration of the functional consequences of these differences. More research is needed to connect the genomic/metabolic potential to specific phenotypic traits or interactions within the host.
Limited mechanistic insights
Although the study shows variation in developmental rates depending on bacterial strains, the underlying mechanisms are not investigated. Further research is needed to understand how the microbiome influences host development on a molecular level.
Rating Explanation
This study presents a valuable resource for C. elegans microbiome research by establishing a defined, ecologically relevant bacterial community. The detailed genomic characterization, combined with the colonization assays and initial phenotypic observations, provides a strong foundation for future studies exploring the complex interplay between host and microbiome. Although some limitations exist regarding the ecological context and in-depth functional analysis, the resource’s potential warrants a good rating.
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File Information
Original Title:
CeMbio - The Caenorhabditis elegans Microbiome Resource
File Name:
document.pdf
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File Size:
3.12 MB
Uploaded:
July 14, 2025 at 11:19 AM
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