Shorter Men Live Longer: Association of Height with Longevity and FOXO3 Genotype in American Men of Japanese Ancestry
Overview
Paper Summary
In a 40-year study of over 8,000 American men of Japanese ancestry, shorter stature was associated with increased lifespan. This may be related to height's association with fasting insulin levels and FOXO3 genotype, a gene linked to longevity and insulin signaling. However, it remains difficult to rule out other confounders like childhood nutrition, which may impact both height and lifespan.
Explain Like I'm Five
In a study of Japanese-American men, shorter men tended to live longer. This might be because height is linked to insulin signaling, which plays a role in aging.
Possible Conflicts of Interest
The study was supported by government grants and the VA. No other conflicts were disclosed.
Identified Limitations
Rating Explanation
This is a decent observational study with a large sample size and long follow-up. However, the specific population and potential confounders limit the generalizability of the findings and prevent a stronger causal claim.
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