Drug formulation and delivery, including pharmaceutics, pharmacokinetics, drug stability, controlled release systems, and the development of novel drug delivery technologies
4 papersThis review summarizes recent progress in using polysaccharide-based hydrogels to deliver therapeutic biomolecules. Polysaccharides like alginate, chitosan, and hyaluronic acid can be formed into hydrogels that can protect biomolecules from degradation and control their release, making them promising drug delivery systems.
Nanoparticle-based drug delivery systems offer improved efficacy for cancer treatment compared to traditional methods by enhancing drug half-life, solubility, and targeted release. This review focuses on chitosan, silica, and PLGA nanoparticles, detailing their fabrication and applications while acknowledging current limitations and future research needs.
This study demonstrates the rapid development and immunogenicity of a novel microneedle array (MNA) delivered recombinant SARS-CoV-2 vaccine. The MNA-delivered vaccine elicited potent and long-lasting antigen-specific antibody responses in mice, suggesting a promising new approach for coronavirus vaccination.
This study developed a cyclodextrin-based nanosponge formulation of griseofulvin that significantly improved drug dissolution, enhanced bioavailability in rats, and effectively masked the bitter taste in a human panel. This approach offers a potential solution for pediatric oral liquid formulations of griseofulvin.