Formulation and evaluation of cyclodextrin-based nanosponges of griseofulvin as pediatric oral liquid dosage form for enhancing bioavailability and masking bitter taste

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Conflicts of Interest

Identified Weaknesses

Rating Explanation

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Paper Summary

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Bye Bye Bitter Medicine: Nano-Sponges Make Griseofulvin Taste-Free for Kids!

This study developed a cyclodextrin-based nanosponge formulation of griseofulvin that significantly improved drug dissolution, enhanced bioavailability in rats, and effectively masked the bitter taste in a human panel. This approach offers a potential solution for pediatric oral liquid formulations of griseofulvin.

Possible Conflicts of Interest

None identified

Identified Weaknesses

Lack of Human Data

The study acknowledges the need for further in vivo absorption studies in humans and clinical investigations in patients to support the obtained results, indicating a lack of human data.

Limited Generalizability to Humans

The study relies on in vitro and in vivo rat data, which may not fully translate to human outcomes. The formulation's effectiveness in humans remains to be confirmed.

Small Sample Size for Taste Masking

While taste masking was evaluated with a human panel, the sample size is small (n=6), potentially limiting the reliability of the findings.

Lack of Long-Term Stability and Scalability Data

The formulation's long-term stability and potential for large-scale manufacturing are not addressed in the study.

Rating Explanation

This study demonstrates a promising approach to enhance the bioavailability and mask the bitter taste of griseofulvin, a crucial factor for pediatric formulations. The methodology is generally sound, including in vitro and in vivo experiments, but the lack of human data and limited generalizability are notable weaknesses.

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Topic Hierarchy

Domain:

Life Sciences

Field:

Pharmacology, Toxicology and Pharmaceutics

Subfield:

Pharmaceutical Science

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Original Title:

Formulation and evaluation of cyclodextrin-based nanosponges of griseofulvin as pediatric oral liquid dosage form for enhancing bioavailability and masking bitter taste

File Name:

pmc7078523.pdf

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File Size:

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July 14, 2025 at 10:54 AM

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