Formulation and evaluation of cyclodextrin-based nanosponges of griseofulvin as pediatric oral liquid dosage form for enhancing bioavailability and masking bitter taste
Overview
Paper Summary
This study developed a cyclodextrin-based nanosponge formulation of griseofulvin that significantly improved drug dissolution, enhanced bioavailability in rats, and effectively masked the bitter taste in a human panel. This approach offers a potential solution for pediatric oral liquid formulations of griseofulvin.
Explain Like I'm Five
Scientists found a way to make tiny, tiny sponges that can carry yucky-tasting medicine for kids. These sponges hide the bitter taste and help the medicine get into their bodies better so it can work.
Possible Conflicts of Interest
None identified
Identified Limitations
Rating Explanation
This study demonstrates a promising approach to enhance the bioavailability and mask the bitter taste of griseofulvin, a crucial factor for pediatric formulations. The methodology is generally sound, including in vitro and in vivo experiments, but the lack of human data and limited generalizability are notable weaknesses.
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