Browse research papers in Biological Psychiatry - Neuroscience Discover 5 academic papers with AI-powered analysis

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Biological Psychiatry

The biological basis of psychiatric disorders, including neurotransmitter systems, brain imaging in psychiatry, genetic factors, psychopharmacology, and biomarkers for mental illness

5 papers in this specialization

Papers

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

The study shows that the AHR pathway, activated by the IDO/TDO-produced metabolite Kynurenine, promotes immunosuppression in the tumor microenvironment by driving a Treg-macrophage suppressive axis. Blocking AHR reverses this immunosuppression and enhances the efficacy of anti-PD-1 therapy in preclinical tumor models.

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s41467-020-17750-z.pdf

Jul 14, 11:22 AM

COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status

This study found that COVID-19 infection significantly alters nitrogen and carbon metabolism, including tryptophan, arginine, sulfur amino acid, glucose, and fatty acid pathways. These metabolic changes correlated with markers of inflammation (IL-6 and CRP) and renal function (BUN and creatinine), suggesting potential targets for therapeutic interventions.

Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study

This Mendelian randomization study found a genetic link between certain immune cell characteristics and schizophrenia. Specifically, some immune cell types seem to have a protective effect against schizophrenia, while changes in others might be a consequence of the disease.

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s12888-023-05081-4.pdf

Jul 14, 11:21 AM

Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway

Edaravone (EDA) shows promise as a treatment for depression and anxiety. It works by activating a specific pathway in the brain (Sirt1/Nrf2/HO-1/Gpx4) and protecting brain cells from damage.

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s12974-022-02400-6.pdf

Jul 14, 11:21 AM

Major depressive disorder: hypothesis, mechanism, prevention and treatment

Major Depressive Disorder (MDD) is a complex disorder with multiple interacting pathogenic factors including genetic predisposition, stress, and comorbidities. The review explores several hypotheses related to MDD, such as the monoamine hypothesis, HPA axis dysfunction, cytokine involvement, and neuroinflammation, highlighting the complex interplay between the brain and other organ systems like the gut and liver, in addition to outlining potential biomarkers and treatments.

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s41392-024-01738-y.pdf

Jul 14, 11:21 AM