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Biological Psychiatry

Biological Psychiatry

The biological basis of psychiatric disorders, including neurotransmitter systems, brain imaging in psychiatry, genetic factors, psychopharmacology, and biomarkers for mental illness
7 papers in this specialization

Paperzilla Papers in Biological Psychiatry

Reticular thalamic hyperexcitability drives autism spectrum disorder behaviors in the Cntnap2 model of autism

This study, conducted in mice, found that increased activity in a brain region called the reticular thalamus (RT) contributes to autism-like behaviors and that suppressing this activity with drugs or genetic techniques improves those behaviors. While promising, it's important to remember that this research was done in mice, so we can't be sure yet if the same will hold true in humans.
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paper_1310.pdf
Sep 09, 08:50 PM

Music therapy as a preventive intervention for postpartum depression: modulation of synaptic plasticity, oxidative stress, and inflammation in a mouse model

This study, conducted on mice, suggests that listening to music may help prevent postpartum depression by reducing inflammation, oxidative stress, and promoting healthy brain function. It found that mice exposed to music and hormone withdrawal (simulating postpartum conditions) showed fewer depression-like behaviors and better neural health compared to mice who only experienced hormone withdrawal. While promising, the study's reliance on a mouse model limits its direct applicability to humans.
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paper_1273.pdf
Sep 08, 06:55 PM

Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine

The study shows that the AHR pathway, activated by the IDO/TDO-produced metabolite Kynurenine, promotes immunosuppression in the tumor microenvironment by driving a Treg-macrophage suppressive axis. Blocking AHR reverses this immunosuppression and enhances the efficacy of anti-PD-1 therapy in preclinical tumor models.
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s41467-020-17750-z.pdf
Jul 14, 11:22 AM

COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status

This study found that COVID-19 infection significantly alters nitrogen and carbon metabolism, including tryptophan, arginine, sulfur amino acid, glucose, and fatty acid pathways. These metabolic changes correlated with markers of inflammation (IL-6 and CRP) and renal function (BUN and creatinine), suggesting potential targets for therapeutic interventions.
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pdf.pdf
Jul 14, 11:22 AM

Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study

This Mendelian randomization study found a genetic link between certain immune cell characteristics and schizophrenia. Specifically, some immune cell types seem to have a protective effect against schizophrenia, while changes in others might be a consequence of the disease.
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s12888-023-05081-4.pdf
Jul 14, 11:21 AM

Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway

Edaravone (EDA) shows promise as a treatment for depression and anxiety. It works by activating a specific pathway in the brain (Sirt1/Nrf2/HO-1/Gpx4) and protecting brain cells from damage.
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s12974-022-02400-6.pdf
Jul 14, 11:21 AM

Major depressive disorder: hypothesis, mechanism, prevention and treatment

Major Depressive Disorder (MDD) is a complex disorder with multiple interacting pathogenic factors including genetic predisposition, stress, and comorbidities. The review explores several hypotheses related to MDD, such as the monoamine hypothesis, HPA axis dysfunction, cytokine involvement, and neuroinflammation, highlighting the complex interplay between the brain and other organ systems like the gut and liver, in addition to outlining potential biomarkers and treatments.
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s41392-024-01738-y.pdf
Jul 14, 11:21 AM
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