Major depressive disorder: hypothesis, mechanism, prevention and treatment
Overview
Paper Summary
Major Depressive Disorder (MDD) is a complex disorder with multiple interacting pathogenic factors including genetic predisposition, stress, and comorbidities. The review explores several hypotheses related to MDD, such as the monoamine hypothesis, HPA axis dysfunction, cytokine involvement, and neuroinflammation, highlighting the complex interplay between the brain and other organ systems like the gut and liver, in addition to outlining potential biomarkers and treatments.
Explain Like I'm Five
Scientists found that when people feel super sad for a long time, it's very complicated. It's not just about their brain, but also how their whole body works, like their tummy, and they are learning new ways to help.
Possible Conflicts of Interest
None identified
Identified Limitations
Rating Explanation
This is a comprehensive review covering a wide range of topics relevant to Major Depressive Disorder. While it serves as a good overview, it lacks critical analysis and synthesis of the literature. The figures could be improved.
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