Organ and tissue transplantation, including donor selection, immunosuppression, rejection prevention, organ preservation, xenotransplantation, and transplant outcomes
3 papersThis report from the ANZDATA Registry found that deceased kidney donor numbers declined in Australia and plateaued in New Zealand during 2019-2020, likely influenced by the COVID-19 pandemic. Live kidney donation remained stable, with New Zealand maintaining a rate more than double that of Australia, accounting for 47% versus 20% of transplants, respectively.
This review paper synthesizes current therapies for kidney transplant rejection, noting that while various treatments exist for both T-cell and antibody-mediated rejection, the efficacy of many, particularly for antibody-mediated rejection, remains questionable due to a lack of high-quality randomized controlled trials. It underscores that rejection continues to significantly impact long-term graft survival, emphasizing the critical need for further research into more effective strategies.
Anemia and iron deficiency frequently occur after kidney transplantation and are linked to poorer patient and transplant outcomes. While some treatments are available, the ideal hemoglobin targets and long-term effects of newer therapies are not fully understood. More research is needed to improve diagnosis, treatment, and clinical practice in this area.