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Pharmacology

Drug action and therapeutics, including clinical pharmacology, drug development, pharmacokinetics, pharmacodynamics, adverse drug reactions, and personalized medicine approaches

10 papers

Papers

DNA fragments detected in monovalent and bivalent Pfizer/BioNTech and Moderna modRNA COVID-19 vaccines from Ontario, Canada: Exploratory dose response relationship with serious adverse events.

This study found significant levels of DNA contamination in all 27 vials of Pfizer and Moderna mRNA COVID-19 vaccines tested. While below FDA guidelines when measured by qPCR, total DNA levels, measured by fluorometry, significantly exceeded recommended limits, potentially impacting safety. A preliminary analysis suggests a correlation between DNA levels and adverse events, warranting further investigation.

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Pharmacology Sep 07, 09:58 AM

Nanocarrier imaging at single-cell resolution across entire mouse bodies with deep learning

This study developed a pipeline called SCP-Nano for tracking nanocarrier delivery in mice at single-cell resolution. Using deep learning and tissue clearing, they tracked mRNA, liposomes, DNA origami, and AAVs across whole mouse bodies, even at low doses, and identified off-target accumulation in the heart after mRNA delivery, potentially explaining cardiac side effects observed in some individuals after mRNA vaccination. While direct applicability to humans is limited by the use of mouse models, this approach provides a valuable tool for preclinical nanomedicine development.

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Pharmacology Aug 26, 04:15 PM

Ivermectin: enigmatic multifaceted ‘wonder' drug continues to surprise and exceed expectations

Ivermectin, already used against parasites, shows promise in combating a wide range of diseases, including some cancers and viruses. However, more research, especially clinical trials, is needed to confirm these preliminary findings and investigate potential side effects. New delivery systems are being explored to improve ivermectin's efficacy and expand its applications.

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Pharmacology Aug 21, 10:37 AM

Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways

This in vitro and in vivo study found that dandelion root extract induced cell death in colon cancer cell lines and inhibited tumor growth in mice xenograft models. The extract appeared to act through multiple cell death pathways. Further research is needed to confirm these findings and to determine the extract's efficacy and safety in humans.

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Pharmacology Aug 18, 04:38 AM

National Pharmacovigilance Assessment of Oral Adverse Events Following COVID-19 Vaccination in Germany (2020-2023)

This German study found that taste disturbances, oral herpes, and swollen tongue were the most common oral adverse events reported after COVID-19 vaccination, echoing similar findings in US data. However, the study relies on passive surveillance data and lacks comparator vaccines/drugs in the German dataset, making it hard to draw firm conclusions about causality or compare reporting rates across different vaccines.

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Pharmacology Jul 22, 07:29 AM

Honeybee venom and melittin suppress growth factor receptor activation in HER2-enriched and triple-negative breast cancer

Honeybee venom and its main component, melittin, show potent anticancer activity against triple-negative and HER2-enriched breast cancer cells by suppressing the activation of EGFR and HER2. Furthermore, melittin synergizes with docetaxel to enhance antitumor effects in an aggressive TNBC allograft model and reduces PD-L1 expression in tumors.

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Pharmacology Jul 14, 10:40 AM

Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response

This study found that melittin-based nanoparticles, when injected into tumors, can effectively activate the immune system and inhibit both local and distant tumor growth. The nanoparticles trigger the release of whole-tumor antigens, stimulating a robust immune response without requiring identification of specific tumor antigens or complex genetic analysis.

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Pharmacology Jul 14, 10:40 AM

Inhibitory Effects of Linear Lipopeptides From a Marine Bacillus subtilis on the Wheat Blast Fungus Magnaporthe oryzae Triticum

This research discovered five linear lipopeptides from a marine Bacillus subtilis strain that demonstrate antifungal activity against the wheat blast fungus, Magnaporthe oryzae Triticum (MoT). These compounds inhibit fungal growth, conidiogenesis, conidial germination, and significantly reduce disease symptoms on detached wheat leaves in laboratory settings, offering a potential new approach for controlling this devastating disease.

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Pharmacology Jul 14, 10:40 AM