Dandelion root extract affects colorectal cancer proliferation and survival through the activation of multiple death signalling pathways
Overview
Paper Summary
This in vitro and in vivo study found that dandelion root extract induced cell death in colon cancer cell lines and inhibited tumor growth in mice xenograft models. The extract appeared to act through multiple cell death pathways. Further research is needed to confirm these findings and to determine the extract's efficacy and safety in humans.
Explain Like I'm Five
Dandelion root extract killed colon cancer cells in a dish and slowed tumor growth in mice, but more research is needed before we know if it works in humans.
Possible Conflicts of Interest
None identified
Identified Limitations
Rating Explanation
This is a pre-clinical study with promising results in vitro and in vivo. However, the research is limited by its use of animal models and a lack of clarity regarding mechanisms of action. It does not warrant a rating higher than a three.
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