Eye diseases and vision disorders, including cataracts, glaucoma, retinal diseases, refractive surgery, pediatric ophthalmology, and advances in ophthalmic surgery
4 papersThis study, conducted in mice and human retinal cells, suggests that the Yamanaka factors (OSK) can protect against age-related vision decline by activating a protein called GSTA4, which helps cells resist oxidative stress. Overexpressing GSTA4 alone improved vision in older mice and even partially reversed age-related changes in gene expression in their retinal cells.
This small study suggests that incandescent lighting might improve visual contrast sensitivity compared to LED lighting, potentially by influencing mitochondrial function. However, more research with larger sample sizes and stricter controls is needed to confirm the effects and their underlying mechanisms. The study did not directly measure mitochondrial function.
In a small study, researchers found that infrared wavelengths in sunlight, and from an 850 nm LED panel, can penetrate the human body. These wavelengths appeared to improve color contrast sensitivity, a measure of visual function. However, the study's small sample size and the unclear real-world significance of the vision improvements limit the strength of these findings.
In a mouse study, researchers found that heterochronic parabiosis (connecting the circulatory systems of young and old mice) and treatment with AdipoR1 agonist AdipoRon could reverse some age-related retinal changes and reduce senescence. The study suggests AdipoR1 may be a therapeutic target for age-related vision loss, though further research is needed.