This review discusses the multifaceted role of glucose metabolism in viral infections, exploring how it supports both immune activation and viral replication. The interplay between immune responses, metabolic reprogramming, and various viral subtypes is highlighted, along with potential therapeutic opportunities for antiviral development.

The authors declare that financial support was received for this research. Research in the Immunology Laboratory at the University of Nizwa is funded by the Oman Ministry of Higher Education, Research, and Innovation (Grant ID: BFP/RGP/HSS/24/015). One of the authors declared they were on the editorial board of the publishing journal but claim it had no influence on peer review or publication.

This review provides a valuable overview of glucose metabolism during viral infections. It explores the complex interactions between glucose metabolism, immune cell function, and viral replication strategies. The review discusses the impact of viral infections on glucose metabolism across various viral subtypes, highlighting the metabolic adaptations observed in different host cells and tissues. It also introduces emerging therapeutic strategies that target glucose metabolism for improved antiviral outcomes. While the review primarily focuses on glucose metabolism, it acknowledges the need for future research into broader aspects of immunometabolism.