This review compares organic bioelectronic transistors (EGOFETs and OECTs) to traditional electrochemical sensors for detecting biological molecules. It argues that organic transistors, by utilizing capacitive coupling and possibly current amplification, could offer greater sensitivity than electrochemical sensors, potentially enabling detection down to the zeptomolar range for certain analytes.

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This is a comprehensive review on a specialized topic within biosensors. It provides a valuable comparison between organic bioelectronic sensors and established electrochemical methods, highlighting potential advantages in sensitivity and miniaturization. Although it could benefit from a broader comparison with other biosensing techniques and a clearer definition of 'amplification factors,' the review offers a good perspective on the potential of this emerging technology.