PAPERZILLA
Crunching Academic Papers into Bite-sized Insights.
About
Sign Out
← Back to papers
Health Sciences › Medicine › Nephrology
0.9% saline versus Plasma-Lyte as initial fluid in children with diabetic ketoacidosis (SPinK trial): a double-blind randomized controlled trial
★
★
★
★
☆
SHARE
Overview
Paper Summary
Conflicts of Interest
Identified Weaknesses
Rating Explanation
Good to know
Topic Hierarchy
File Information
Paper Summary
Paperzilla title
Plasma-Lyte vs. Saline: A Draw in the DKA Hydration Duel!
In children with diabetic ketoacidosis (DKA), Plasma-Lyte-A and 0.9% saline showed similar rates of new or progressive acute kidney injury (AKI) and resolution of AKI. No differences were found between the two fluids for time to DKA resolution, need for renal replacement therapy, mortality, or length of ICU/hospital stay.
Possible Conflicts of Interest
None identified
Identified Weaknesses
Underpowered study
The study is underpowered, as the occurrence of the primary outcome was low in both groups, limiting the ability to draw definitive conclusions.
Single-center study
The single-center design limits the generalizability of the findings to other populations and settings.
Stringent AKI definition
The definition of AKI used in the study was stringent, potentially inflating the incidence of AKI compared to previous studies and clinical practice.
Lack of analysis on clinical significance
The study did not analyze the clinical significance of preventing hyperchloremic acidosis, leaving a gap in understanding the practical implications of using Plasma-Lyte-A.
Limited exploration of dose-related effects
The study did not explore dose-related effects of hyperchloremia, limiting the understanding of fluid volume's impact on AKI.
Rating Explanation
This is the first double-blind randomized controlled trial comparing Plasma-Lyte-A and 0.9% saline in pediatric DKA. The study had a stringent methodology, meticulous monitoring, and near-complete adherence to protocol. Despite being underpowered and limited by its single-center design, it provides valuable insights into fluid management in high-risk DKA patients.
Good to know
This is our free standard analysis. Paperzilla Pro fact-checks every citation, researches author backgrounds and funding sources, and uses advanced AI reasoning for more thorough insights.
Explore Pro →
Topic Hierarchy
File Information
Original Title:
0.9% saline versus Plasma-Lyte as initial fluid in children with diabetic ketoacidosis (SPinK trial): a double-blind randomized controlled trial
File Name:
s13054-019-2683-3.pdf
[download]
File Size:
0.75 MB
Uploaded:
July 14, 2025 at 11:09 AM
Privacy:
🌐 Public
© 2025 Paperzilla. All rights reserved.